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HomecompanyDoxorubicin hydrochloride
Doxorubicin hydrochloride
Doxorubicin hydrochloride

Doxorubicin hydrochloride

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameDoxorubicin hydrochloride
  • CAS No.25316-40-9
  • EINECS No.246-818-3
  • MFC27H29NO11.ClH
  • MW579.98
  • Appearancesolidorange to dark red
  • Melting point 216 °C (dec.)(lit.)
  • storage temp. 2-8°C
  • Water Solubility Soluble in water.

AD68

Product Name: Doxorubicin hydrochloride
Synonyms: ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE
CAS: 25316-40-9
MF: C27H30ClNO11
MW: 579.98
EINECS: 246-818-3
Product Categories: APIs;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Adriamycin;inhibitor;Anti-cancer&immunity;Inhibitors
Mol File: 25316-40-9.mol
Doxorubicin hydrochloride Structure
 
Doxorubicin hydrochloride Chemical Properties
Melting point  216 °C (dec.)(lit.)
alpha  D20 +248±2° (c = 0.1 in methanol)
storage temp.  2-8°C
solubility  H2O: 10 mg/mL, clear, red-orange
color  orange to dark red
Water Solubility  Soluble in water.
λmax 497nm(H2O)(lit.)
Merck  14,3439
InChIKey MWWSFMDVAYGXBV-RUELKSSGSA-N
CAS DataBase Reference 25316-40-9(CAS DataBase Reference)
EPA Substance Registry System 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)
 
Safety Information
Hazard Codes  T,T+,Xi
Risk Statements  45-22-40-26/27/28-36/38
Safety Statements  53-45-36/37/39-22-7/9
WGK Germany  3
RTECS  QI9295900
F  10-21
HS Code  29419090
Toxicity LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)
Doxorubicin hydrochloride Usage And Synthesis
Chemical Properties Orange-Red Crystalline Solid
Uses Used as an antineoplastic
Uses Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
Uses Antibacterial;DNA intercalant
Uses Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Uses Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Uses Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]
General Description Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.
Air & Water Reactions Water soluble.
Reactivity Profile Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard Doxorubicin hydrochloride is probably combustible.
Biological Activity Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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