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β-ESTRADIOL
β-ESTRADIOL

β-ESTRADIOL

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product Nameβ-ESTRADIOL
  • CAS No.50-28-2
  • EINECS No.200-023-8
  • MFC18H24O2
  • MW272.39
  • InChIKeyVOXZDWNPVJITMN-RBWZDWSONA-N
  • AppearancepowderWhite to off-white
  • storage temp. room temp
  • Melting point 178-179 °C(lit.)
  • Water Solubility Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
  • Boiling point 355.44°C (rough estimate)
  • density 1.0708 (rough estimate)

AD68

β-ESTRADIOL Basic information
Indications and Usage Adverse reactions Contradictions
Product Name: β-ESTRADIOL
Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol
CAS: 50-28-2
MF: C18H24O2
MW: 272.38
EINECS: 200-023-8
Product Categories: Steroids;Estrogen;Hormone;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;VIVELLE;Hormone Drugs;Inhibitors;powder or crystal
Mol File: 50-28-2.mol
β-ESTRADIOL Structure
 
β-ESTRADIOL Chemical Properties
Melting point  178-179 °C(lit.)
alpha  D25 +76 to +83° (dioxane)
Boiling point  355.44°C (rough estimate)
density  1.0708 (rough estimate)
refractive index  80.4 ° (C=1, Dioxane)
Fp  2℃
storage temp.  2-8°C
form  powder
color  White to off-white
Water Solubility  Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck  14,3703
BRN  1914275
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference 50-28-2(CAS DataBase Reference)
NIST Chemistry Reference Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System Estra-1,3,5(10)- triene-3,17-diol (17.beta.)-(50-28-2)
 
Safety Information
Hazard Codes  T,Xn,F
Risk Statements  60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements  53-22-36/37/39-45-36/37-26-16-36-20
RIDADR  2811
WGK Germany  3
RTECS  KG2975000
F  8-10
HazardClass  6.1
PackingGroup  III
HS Code  29372390
Hazardous Substances Data 50-28-2(Hazardous Substances Data)
β-ESTRADIOL Usage And Synthesis
Indications and Usage Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
Adverse reactions In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
Contradictions Do not use on breasts, vaginal area and vaginal mucosa.
Chemical Properties White Crystalline Powder
Uses Potent mammalian estrogenic hormone produced by the ovary.
Uses Estradiol is the major estrogen secreted by the premenopausal ovary.
Definition ChEBI: The 17beta-isomer of estradiol.
Biological Activity Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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