Baicalein
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameBaicalein
- CAS No.491-67-8
- EINECS No.000-000-0
- MFC15H10O5
- MW270.24
- AppearanceYellow solidYellow or yellow-green
- storage temp. Keep in dark place,Sealed in dry,2-8°C
- Melting point 256-271 °C (lit.)
- Boiling point 373.35°C (rough estimate)
- density 1.3280 (rough estimate)
AD68
| Baicalein Basic information |
| Product Name: | Baicalein |
| Synonyms: | BAICALEIN(SH)NOW RG GRADE;Baicalein, monohydrate, 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one monohydrate;Baicelein;Noroxylin;5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one;Baicalein 98%;5,6,7-trihydroxy-2-phenyl-4-chromenone hydrate;5,6,7-trihydroxy-2-phenyl-chromen-4-one hydrate |
| CAS: | 491-67-8 |
| MF: | C15H10O5 |
| MW: | 270.24 |
| EINECS: | |
| Product Categories: | Aromatics;Heterocycles;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Tri-substituted Flavones;The group of Scutellaria;Inhibitors |
| Mol File: | 491-67-8.mol |
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| Baicalein Chemical Properties |
| Melting point | 256-271 °C(lit.) |
| Boiling point | 373.35°C (rough estimate) |
| density | 1.3280 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | 2-8°C |
| Merck | 14,942 |
| BRN | 272683 |
| CAS DataBase Reference | 491-67-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DJ3100898 |
| Hazard Note | Irritant |
| Baicalein Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid |
| Uses | antiviral (HIV) |
| Uses | An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs. |
| Uses | inhibitor of lipoxidase and leukotriene biosynthesis |
| Uses | An inhibitor of Ca2+ uptake, 5-LO, and 12-LO |
| Definition | ChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. |
| Uses | Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 μM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM). Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 μM. In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 μg/ml. |
| Biological Activity | Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo . |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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