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HomecompanyDexamethasone 21-phosphate disodium salt
Dexamethasone 21-phosphate disodium salt
Dexamethasone 21-phosphate disodium salt

Dexamethasone 21-phosphate disodium salt

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameDexamethasone 21-phosphate disodium salt
  • CAS No.2392-39-4
  • EINECS No.219-243-0
  • MFC22H28FNa2O8P
  • MW516.4
  • AppearanceWhite Powderwhite to off-white
  • storage temp. 2-8°C
  • Melting point 233-235 °C
  • Water Solubility Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.

AD68

Dexamethasone 21-phosphate disodium salt Basic information
Summary Anti-inflammatory drugs Characteristic Pharmacology effect Pharmacokinetics Adverse Reaction Medicine interactions Precautions Special people medication Medication contraindication Dosage Storage Usage References
Product Name: Dexamethasone 21-phosphate disodium salt
Synonyms: decadronphosphate;dexadreson;dexagro;dexamethasonedisodiumphosphate;disodiumdexamethasonephosphate;disodiumsalt,(11beta,16alpha)-y);megacort;pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonoox
CAS: 2392-39-4
MF: C22H28FNa2O8P
MW: 516.4
EINECS: 219-243-0
Product Categories: Immunomodulators and AntibioticsLipids;Steroids (C21) and Derivatives;Immune Cell Signaling and Blood;Immune System Regulation;Sterols;Pharmaceutical intermediate;API;HEXADROL;Hormone Drugs
Mol File: 2392-39-4.mol
Dexamethasone 21-phosphate disodium salt Structure
 
Dexamethasone 21-phosphate disodium salt Chemical Properties
Melting point  233-235 °C
alpha  D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, faintly yellow
form  White Powder
color  white to off-white
Water Solubility  Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
Merck  13,2960
InChIKey PLCQGRYPOISRTQ-FCJDYXGNSA-L
CAS DataBase Reference 2392-39-4(CAS DataBase Reference)
EPA Substance Registry System Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17-dihydroxy-16- methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.alpha.)-(2392-39-4)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-40-63
Safety Statements  36/37/39
WGK Germany  3
RTECS  TU4056000
F  3-10
TSCA  Yes
Dexamethasone 21-phosphate disodium salt Usage And Synthesis
Summary Dexamethasone 21-phosphate disodium salt is a system glucocorticoid with anti-inflammatory properties, is the pro-drug which is converted to dexamethasone in vivo. It stimulates uptake of glutamine in the cerebral cortex and induces apoptosis. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. 
It is freely soluble in water, slightly soluble in ethanol, and insoluble in chloroform and in ether. It is an inhibitor of the sodium phosphate symporter and GR activator. 
Additionally, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.
Anti-inflammatory drugs Dexamethasone sodium phosphate (DSP), chemical name 16a-methyl-11β,17a,21-trihydroxy-9a-fluoropregna-1,4-diene-3,20-dione-21-Phosphate disodium salt, belongs to the adrenal cortex hormones. It has the effect of antiphlogosis by stabilizing the lysosomal membrane, reducing the release of lysosomal hydrolase; inhibiting the formation of  inflammation-induced material  bradykinin, serotonin and prostaglandin, increasing the stability of mast cells particles, reducing the release of histamine, concentrate blood vessels, stop white blood cells and macrophages from migrating outside of the blood vessels, etc. It can inhibit macrophage function to play immunization function and inhibit the formation of fibroblasts which is conducive to prevent corneal scar. When used for trauma, it can stop scar from forming and protect eyesight. It can inhibit or reduce the formation of new vessel in the cornea and conjunctiva disease and alleviate rejection reaction and scar formation in local use. In clinical treatment it can be used for autoimmune diseases, allergies, inflammation, rheumatism, asthma, ophthalmology and dermatology and other diseases.
Characteristic This product is white or off-white powder; odorless with slightly bitter taste and hygroscopicity. It can dissolve in water or methanol but is almost insoluble in acetone or ether. Melting point 233-235 ℃.
Pharmacology effect
  • Antiinflammatory effect
This product can relieve and prevent the reaction of organization to inflammation. In the early stage of acute inflammation, it can reduce the exudation of local edema by inhibiting capillary permeability, leukocyte infiltration and phagocytosis and reducing the release of various inflammatory mediators In the late inflammatory phase, it can inhibit capillary and fibroblast proliferation and collagen protein synthesis to prevent adhesion and scar formation.
  • Immunity inhibition and anti-allergic effects
This product can prevent or inhibit cell-mediated immune response, delayed allergic reactions,reduce the number of T lymphocytes, monocytes and brucella cells, reduce the integration ability between immunoglobulin and cell surface receptors and inhibit interleukin synthesis and release, thus inhibting the transformation of T lymphocytes to lymphocyte and pathological changes caused by allergic reactions such as allergic congestion, edema, exudation, rash, smooth muscle spasm, cell damage. and so on. This product also prevents the immune replenishment from getting through the basement membrane and can reduce the complement component and immunoglobulin concentration. In addition it can inhibit the transplant rejection reaction of tissue and organ and has certain short-term effect on autoimmune diseases.
  • The treatment effect on ophthalmic diseases
Inhibition of corneal epithelial regeneration, in the cornea, conjunctival disease can inhibit or reduce the formation of new blood vessels.
Pharmacokinetics This product is adrenal corticosteroid drugs. Its effect is similar to  hydrocortisone but stronger with anti-inflammatory effect 40-50 times that of hydrocortisone and more notable effect of anti-inflammatory, anti-allergy, anti-shock than prednisone. It has quick efficacy and less side effects improving the body function in short time especially for the forst aid in critical illnesses.
This product affects sugar metabolism and has strong function of  anti-inflammatory, anti-inflammatory, anti-inflammatory and anti-allergy It  affects water and sodium retention slightly and has strong inhibitory effect on pituitary-adrenal so it just causes slight side effects such as edema, hypertension,muscle weakness and so on. This product transpires through kidneys in urine after metabolic transformation in liver so the drug's plasma half-life can extend for people with liver and renal dysfunction.
The concentration reaches plasma peak one hour after intramuscular and plasma protein binding rate is lower than other corticosteroids drug.
Adverse Reaction
  • The main adverse reactions of this product is concurrent infection, including fungi, tuberculosis, staphylococcus, proteus, pseudomonas aeruginosa and a variety of herpes virus
  • Long-term use can cause iatrogenic Cushing's syndrome.
  •  For patients suffering from chronic wasting disease or mental disorders before, such mental symptoms may occur:euphoria, excitement, delirium, anxiety, orientation disorder or inhibition.
  • Some patients with long-term local drug use may suffer hormone glaucoma and hormone cataracts.
  • Glucocorticoid withdrawal syndrome. Sometimes the patient stop taking medicine may suffer dizziness, fainting tendencies, abdominal pain or back pain, fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, weakness, which can be considered to be glucocorticoid-dependent syndrome adrenal insufficiency and the recurrence of original disease are excluded after careful examination.
Medicine interactions
  • The decomposition of this product can be speeded and metabolic promotion is weakened if taken with barbiturates, phenytoin, rifampicin and other liver enzyme inducer
  • The toxicity increases combined with salicylic acid
  • The product can reduce the effect of anticoagulant and oral hypoglycemic and attention should be paid adjust the dose.
  • Incompatible with hydrochloric vancomycin
Precautions
  • Patients with tuberculosis, acute bacterial or viral infections must be given appropriate anti-infective treatment.
  • For eye infections combined with effective antibiotics. Patients with
  • corneal ulcers are not permitted. When patient’s condition turns better dose times should be gradually reduced in case of recurrence.
  • Patients with diabetes, osteoporosis, cirrhosis, renal dysfunction, and hypothyroidism should be cautious to take.
  • After long-term medication, dosage should be gradually reduced before stop.
  • Athletes with caution.
Special people medication
  • Pregnant women and lactatinal women medication
This product with teratogenic effect in animal test can increase the probability of placental insufficiency, neonatal weight loss or stillbirth. So the pregnant women should weight advantages and disadvantages before taking it. Nannie receiving high-dose administration should not breast feed, in case of drug transpiring through milk resulting in infant growth inhibition, adrenal function inefficiency and other adverse reactions
  • Children medication
Be careful in giving infant adrental cortex hormones administration because it can inhibit infant from growth and development. If long-term use is necessary, short-acting or medium-acting agents should be used instead of long-acting dexamethasone preparations and changes in intracranial pressure should be observed.
  • Old people medication
Easy to suffer high blood pressure and diabetes. For old patients especially after-menopaue women the osteoporosis.tends to be severer.
Medication contraindication Patients with allergic history to this product and adrenal corticosteroids should not be permitted and in special case pros and cons should be weighed before use .Pay attention to the deterioration of the disease: It is not suitable for patients with hypertension, thrombosis, stomach and duodenal ulcer, psychosis, electrolyte metabolism, myocardial infarction , visceral surgery, glaucoma and so on.
Dosage Eye drops: dexamethasone sodium phosphate eye drops, 5ml: 1.25mg.
Injection: dexamethasone sodium phosphate injection, 1ml: 5mg, 1ml: 2mg.
Dexamethasone sodium phosphate for injection, 10mg (based on dexamethasone sodium phosphate).
New formulation: dexamethasone sodium phosphate temperature-sensitive in situ gel.
dexamethasone sodium phosphate injection
Figure 1 is dexamethasone sodium phosphate injection
Storage Away from light. Sealed. Stored in dry place at 4℃
Usage
  • Adrenal corticosteroids drug, anti-inflammatory, anti-toxity, anti-allergy;
  • An anti-excitment glucocorticoid and also a precursor drug that can be converted into dexamethasone in body stimulating glutamate to be absorbed into the cerebral cortex. It is used as adrenal corticosteroids clinically with anti-inflammatory, anti-drug and anti-allergy effect.
References https://www.alfa.com/zh-cn/catalog/J64083/
http://www.tcichemicals.com/eshop/en/jp/commodity/D4438/
https://www.goldbio.com/product/4827/dexamethasone-21-phosphate-disodium-salt
Uses glucocorticoid, antiinflammatory
Definition ChEBI: An organic sodium salt which is the disodium salt of dexamethasone phosphate.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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