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Esomeprazole
Esomeprazole

Esomeprazole

Price USD1.00
Packge 1KG
  • Min. Order:1KG
  • Supply Ability:1000kg
  • Time:2019-07-06

Product Details

  • Product NameEsomeprazole
  • CAS No.119141-88-7
  • EINECS No.201-212-8
  • MFC17H19N3O3S
  • MW345.42
  • AppearanceA solid
  • Boiling point 600.0±60.0 °C(Predicted)
  • density 1.37±0.1 g/cm3(Predicted)
  • storage temp. Sealed in dry,Room Temperature

JD607

Product Name: Esomeprazole
Synonyms: Esomeprazole(Na、Mg);(5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfoniumolate;(S)-Esomeprazole;Esomeprazole(Mg);5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1H-benzimidazole;6-Methoxy-2-[(R)-(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-benzoimidazole;Esomeprazole;EsoMeprazole EC Pellets 22%
CAS: 119141-88-7
MF: C17H19N3O3S
MW: 345.42
EINECS: 201-212-8
Product Categories: API
Mol File: 119141-88-7.mol
Esomeprazole Structure
 
Esomeprazole Chemical Properties
alpha  D20 -155° (c = 0.5 in chloroform)
CAS DataBase Reference 119141-88-7(CAS DataBase Reference)
 
Safety Information
MSDS Information
 
 
Esomeprazole Usage And Synthesis
General Description Esomeprazole (English brand name: Inexium), is the S-isomer of omeprazole. In 1990, in vitro gastric gland model confirmed that two isomers of omeprazole have the same proton pump inhibitory effect. However, it was not possible at that time to prepare a sufficient number of individual isomers for in vivo testing, and the isolated isomers could be slowly racemized in aqueous solution. When sufficient amounts of both isoforms were available for human tesing, the effect of the oral S-isomer was proved to be about 4 times better than that of the R-isomer. Esomeprazole decreases the amount of acid produced in the stomach through specific targeting. It is weakly alkaline and works as a specific inhibitor of proton pumps in parietal cells. Also it concentrates and transforms into an active form in the acid environment of the parietal oxynticus microtubules, thus inhibiting H / K-ATPase (proton pump) of this body part and inhibiting the the secretion of basic gastric acid and stimulated gastric acid. Its curative effects for gastroesophageal reflux disease are better than omeprazole in terms of symptoms relief, inhibition of gastric acid produced in the stomach and promoting the improvement of esophagitis.
Indication
  1. Gastroesophageal reflux disease (GERD) is when food or liquid travels from the stomach back up into the esophagus, often causing heartburn, acid reflux, retrosternal pain and other symptoms, and also causing pathologic damage to esophageal mucosa. GERD is one of the common clinical acid-related diseases, and the key to treat the gastroesophageal reflux disease is to inhibit gastric acid secretion. Esomeprazole (eaomeprazole) is the laevo isomer of omeprazole (Nexium), used to treat eflux esophagitis with quick effect and good acid suppression. It can be used alone or in combination with Prokinetic agent or gastrointestinal mucosal protective agent,and its curative effect is better than other PPI (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole),Also it’s safe and effective for the elderly and children infected with reflux esophagitis.
  2. Erosive reflux esophagitis treatment
  3. Long-term maintenance for healed esophagitis patients.
  4. To control symptoms of gastroesophageal reflux disease (GERD) and combine with appropriate antimicrobial therapy to eradicate ofHelicobacter pylori
  5. To heal the Helicobacter pylori-related duodenal ulcer
  6. To prevent the Helicobacter pylori -related peptic ulcer recurrence.
Usage and Dosage Swallow the tablet together with the liquid. Don’t chew or crush.
  • Gastroesophageal Reflux Disease (GERD)
1. Erosive reflux esophagitis treatment: 40mg once a day. 
Duration of therapy: four weeks.
2. An additional 4 weeks may be considered for patients with esophagitis not healed or the symptoms don’t resolve after initial treatment. Long-term maintenance for healed esophagitis patients: 20mg once a day.
3. Gastroesophageal reflux disease (GERD) symptom control
Patients without esophagitis: 20mg once a day. If symptoms are not controlled after 4 weeks, further examinations should be done to the patient. Once the symptoms have been resolved, 20 mg orally once a day should be taken to maintain the symptom resolution and healing.
4. Combine with appropriate antibiotic therapy to eradicate Helicobacter pylori, heal the Helicobacter pylori-related duodenal ulcer and prevent the Helicobacter pylori -related peptic ulcer recurrence.  
Triple therapy: esomeprazole 20 mg + amoxillin 1 g + clarithromycin 500mg, twice a day. Duration of therapy: 7 days.
Side effects
  1. None of the following side effects have been found dose-related. 
  2. Common side effects (> 1/100, <1/10): headache, stomach pain, diarrhea, bloating, nausea / vomiting, constipation. 
  3. Rare side effects (> 1/1000, <1/100): dermatitis, itching, hives, dizziness, dry mouth. 
  4. The following side effects have been observed in the use of racemaic modification (omeprazole), and therefore they may also occur during the use of esomeprazole.
Definition ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium alt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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