Esomeprazole
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:100kg
- Time:2019-07-06
Product Details
- Product NameEsomeprazole
- CAS No.119141-88-7
- EINECS No.201-212-8
- MFC8H6O2
- MW134.13
- InChIKeyACZGCWSMSTYWDQ-UHFFFAOYSA-N
- AppearanceCrystalline Powder or CrystalsWhite to yellow-orange
- density 1,22 g/cm3
- Melting point 49-51 °C(lit.)
- Boiling point 248-250 °C(lit.)
- storage temp. Sealed in dry,Room Temperature
JD607
| Product Name: | Esomeprazole |
| Synonyms: | Esomeprazole(Na、Mg);(5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfoniumolate;(S)-Esomeprazole;Esomeprazole(Mg);5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1H-benzimidazole;6-Methoxy-2-[(R)-(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-benzoimidazole;Esomeprazole;EsoMeprazole EC Pellets 22% |
| CAS: | 119141-88-7 |
| MF: | C17H19N3O3S |
| MW: | 345.42 |
| EINECS: | 201-212-8 |
| Product Categories: | API |
| Mol File: | 119141-88-7.mol |
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| Esomeprazole Chemical Properties |
| alpha | D20 -155° (c = 0.5 in chloroform) |
| CAS DataBase Reference | 119141-88-7(CAS DataBase Reference) |
| Esomeprazole Usage And Synthesis |
| General Description | Esomeprazole (English brand name: Inexium), is the S-isomer of omeprazole. In 1990, in vitro gastric gland model confirmed that two isomers of omeprazole have the same proton pump inhibitory effect. However, it was not possible at that time to prepare a sufficient number of individual isomers for in vivo testing, and the isolated isomers could be slowly racemized in aqueous solution. When sufficient amounts of both isoforms were available for human tesing, the effect of the oral S-isomer was proved to be about 4 times better than that of the R-isomer. Esomeprazole decreases the amount of acid produced in the stomach through specific targeting. It is weakly alkaline and works as a specific inhibitor of proton pumps in parietal cells. Also it concentrates and transforms into an active form in the acid environment of the parietal oxynticus microtubules, thus inhibiting H / K-ATPase (proton pump) of this body part and inhibiting the the secretion of basic gastric acid and stimulated gastric acid. Its curative effects for gastroesophageal reflux disease are better than omeprazole in terms of symptoms relief, inhibition of gastric acid produced in the stomach and promoting the improvement of esophagitis. |
| Indication |
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| Usage and Dosage | Swallow the tablet together with the liquid. Don’t chew or crush.
Duration of therapy: four weeks. 2. An additional 4 weeks may be considered for patients with esophagitis not healed or the symptoms don’t resolve after initial treatment. Long-term maintenance for healed esophagitis patients: 20mg once a day. 3. Gastroesophageal reflux disease (GERD) symptom control Patients without esophagitis: 20mg once a day. If symptoms are not controlled after 4 weeks, further examinations should be done to the patient. Once the symptoms have been resolved, 20 mg orally once a day should be taken to maintain the symptom resolution and healing. 4. Combine with appropriate antibiotic therapy to eradicate Helicobacter pylori, heal the Helicobacter pylori-related duodenal ulcer and prevent the Helicobacter pylori -related peptic ulcer recurrence. Triple therapy: esomeprazole 20 mg + amoxillin 1 g + clarithromycin 500mg, twice a day. Duration of therapy: 7 days. |
| Side effects |
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| Definition | ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium alt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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