Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
China United Kingdom South Korea Germany Japan India
Inquriy
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomecompanyValsartan
Valsartan
Valsartan
Valsartan
Valsartan

Valsartan

Price USD100.00
Packge 25KG
  • Min. Order:1KG
  • Supply Ability:customise
  • Time:2019-07-06

Product Details

  • Product NameValsartan
  • CAS No.137862-53-4
  • EINECS No.1592732-453-0
  • MFC24H29N5O3
  • MW435.52
  • Appearancepowderwhite to tan
  • Melting point 116-117°C
  • storage temp. 2-8°C
  • Boiling point 684.9±65.0 °C(Predicted)
  • density 1.212±0.06 g/cm3(Predicted)
  • Water Solubility 84.99mg/L(25 ºC)
Product Name: Valsartan
Synonyms: L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;Ambroxol Hydrochloride Imp.D;3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic aci;(S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]amine;(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic aci;VALSARTAN IMP C;Valsartan,99%e.e.;N-(1-OXOPENTYL)-N-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-L-VALINE
CAS: 137862-53-4
MF: C24H29N5O3
MW: 435.52
EINECS: 1592732-453-0
Product Categories: Inhibitors;Active Pharmaceutical Ingredients;Antihypertensive;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Aromatics;Chiral Reagents;Heterocycles;API Reference Standard Free Base API;DIOVAN
Mol File: 137862-53-4.mol
Valsartan Structure
 
Valsartan Chemical Properties
Melting point  116-117°C
storage temp.  -20°C Freezer, Under inert atmosphere
solubility  DMSO: ≥20mg/mL
color  white to tan
Merck  14,9916
Stability: Hygroscopic
InChIKey ACWBQPMHZXGDFX-QFIPXVFZSA-N
CAS DataBase Reference 137862-53-4(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
RTECS  YV9455000
Hazardous Substances Data 137862-53-4(Hazardous Substances Data)
 
Valsartan Usage And Synthesis
Indications and Usage Valsartan is a type of specific angiotensin I (AT1) receptor antagonist and a clinical non-dermal AT1 receptor antagonist following losartan that has important effects in adjusting bodily blood pressure and maintaining electrolyte-body fluid balance. Valsartan’s antihypertensive effects are stronger than those of enalapril and is suitable for treating hypertension, mild to moderate primary hypertension, and especially secondary hypertension caused by renal damage. It can significantly reduce proteinuria for hypertension patients with diabetes or normal liver functions, and it can promote uric acid and urinary sodium to protect the kidney. Valsartan is also suitable for reducing the cardiovascular mortality for high risk patients (left ventricular failure or dysfunction) after experiencing a heart attack.
Mechanisms of Action Valsartan selectively affects the AT1 receptor subtype and prevents AT1 from binding with AT1 receptors (its selective AT1 receptor antagonizing effect is about 20000 times greater than its effects on AT2 receptors), thus inhibiting vasoconstriction and aldosterone release, producing an antihypertensive effect, but it cannot inhibit the release of aldosterone caused by potassium ions (K+). Valsartan does not affect angiotensin-converting enzymes (ACE) or renin and its receptors, and it does not inhibit ion channels related to blood pressure regulation and sodium balance. Valsartan does not inhibit ACE and does not affect bodily bradykinin levels, thus causing less coughing side effects than ACE inhibitors. Valsartan does not affect heart rate when lowering blood pressure. Sudden ceasing in Valsartan use will not cause rebound hypertension or other side effects. Valsartan does not affect hypertension patients’ overall cholesterol, triglyceride, blood glucose, or uric acid levels.
Pharmacokinetics For most patients, a single oral dose will have antihypertensive effects that occur within 2 hours, peak at 4-6 hours, and continue for over 24 hours. 2-4 weeks of treatment will result in maximum hypertensive curative effects, which will last throughout long-term treatment. It can be used with thiazide diuretics to further strengthen antihypertensive effects.
Clinical Research A clinical trial showed that Valsartan has very noticeable effects on mild to moderate hypertension. A daily dose of ≥80 mg can effectively control systolic and diastolic blood pressure while not affecting blood pressure’s circadian rhythm; a daily 160mg dose has more noticeable effects than a daily 100mg dose of losartan. Moderate hypertension patients with intact renal functions have a good tolerance towards Valsartan, Valsartan’s curative effects are significantly superior to those of ACE inhibitors, and there are minimal adverse reactions. Effective in treating severe hypertension when combined with other antihypertensive drugs.
Chemical Properties White Crystalline Powder
Uses A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Uses Angiotensin II inhibitor, antihypertensive
Uses May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second l
Definition ChEBI: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

Recommended supplier

career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
HomePage About Us Contact us Terms Privacy Chemicalbook
Land Line: 040 - 40102781 Mobile contact: +91 9550333722