Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomecompanyTenofovir
Tenofovir
Tenofovir

Tenofovir

Price USD130.00
Packge 1G
  • Min. Order:1G
  • Supply Ability:1kg
  • Time:2019-07-06

Product Details

  • Product NameTenofovir
  • CAS No.147127-20-6
  • EINECS No.240-723-0
  • MFC9H14N5O4P
  • MW287.21
  • Appearancepowderwhite to beige
  • Melting point 276-280°C
  • Water Solubility 13.4 mg/mL (25 ºC)
  • storage temp. -20°C
  • Boiling point 616.1±65.0 °C(Predicted)
  • density 1.79±0.1 g/cm3(Predicted)

CR29

Tenofovir Basic information
Indications and Usage Mechanisms of Action Pharmacokinetics Adverse Effects
Product Name: Tenofovir
Synonyms: 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;(R)-9-(2-Phosphonomethoxypropyl)Adenine;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
EINECS: 1308068-626-2
Product Categories: Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Inhibitors
Mol File: 147127-20-6.mol
Tenofovir Structure
 
Tenofovir Chemical Properties
Melting point  276-280°C
alpha  D +21° (c = 1 in 0.1M HCl)
storage temp.  Store at -20°C
Water Solubility  13.4 mg/mL (25 ºC)
Merck  14,9146
CAS DataBase Reference 147127-20-6(CAS DataBase Reference)
 
Safety Information
RTECS  SZ6563600
MSDS Information
 
 
Tenofovir Usage And Synthesis
Indications and Usage Tenofovir disoproxil (Viread) is the first nucleotide analogue approved by the American FDA to treat HIV-1 infections. Tenofovir disoproxil is a drug used in the AIDS cocktail treatment method, and research shows that it has the ability to increase monkeys’ immunity to immunodeficiency viruses (similar to the human AIDS virus). Tenofovir disoproxil is used in combination with other reverse transcriptase inhibitors to treat HIV-1 infections and hepatitis B.
Mechanisms of Action Tenofovir disoproxil is an acyclic nucleoside antivirus drug and has an inhibiting effect on HBV multi-enzyme complexes and HIV reverse transcriptase. Its active content tenofovir phosphonate directly competitively binds to natural deoxyribose substrate to inhibit the virus multi-enzyme complex and inserts itself into the DNA to end the nucleotide chain. Tenofovir disoproxil is barely absorbed by the gastrointestinal duct, so it undergoes esterification and ionization to become tenofovir ester fumarate. Tenofovir is soluble in water and can be quickly absorbed and decomposed into the active substance tenofovir, which then transforms into the active metabolite tenofovir phosphonate. As this drug is not metabolized by the CYP450 enzyme system, it has a very low chance of drug interactions caused by this enzyme.
Pharmacokinetics Tenofovir disoproxil reaches peak blood concentration 1-2 hours after intake. Tenofovir disoproxil’s bioavailability increases by about 40% when taken with food. The intracellular half-life of tenofovir phosphonate is about 10 hours, so doses can be taken once daily. This drug is mainly filtered through renal glomeruli and excreted through the renal tubule transport system, with 70-80% excreted in its original form through urine.
Adverse Effects
  • Weakness and exhaustion.
  • Mild to moderate gastrointestinal reactions, including diarrhea, stomach pain, nausea, vomiting, bloating, lactic acid poisoning, hepatomegaly and fatty liver, and pancreatitis. These adverse reactions also commonly appear individually or combined when taking nucleoside analogues.
  • Metabolic system hypophosphatemia (1% occurrence rate).
  • Fat accumulation and redistribution, including centripetal obesity, buffalo hump, thin limbs, breast growth, and Cushing syndrome.
  • May cause lactic acid poisoning, hepatomegaly related to steatosis, etc.
  • Effects on nervous system: dizziness and headache.
  • Effects on respiratory system: difficulty breathing.
  • Effects on skin: drug rash.
Chemical Properties White Crystalline Solid
Uses Tenofovir is a drug used for the treatment of chronic heptatitis B as well as prevention and treatment of HIV/AIDS. It is a kind of nucleotide analog, acting as the reverse-transcriptase inhibitor (NtRTI). It inhibits the activity of HIV reverse transcriptase through competing with the natural substrate deoxyadenosine 5’-triphosphate, causing the termination of DNA chain. 
Definition ChEBI: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxy ethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY