Medical chemicals Etomidate CAS 33125-97-2
Price | USD10.00 |
Packge | 1kg |
- Min. Order:10kg
- Supply Ability:200tons
- Time:2022-07-20
Product Details
- Product Name2-Acetoxy-2-methyl-6-methylene-7-octene
- CAS No.331255-97-2
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Use of Etomidate
Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.Target: GABA ReceptorEtomidate is a potent inhibitor of the adrenal response to surgery. The absence of clinical consequences associated with the blunted response suggests that a major increase in adrenal hormone production may not be necessary during surgery [1]. Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure [2]. Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality [3].Clinical indications: FDA Approved Date: 1983Toxicity: Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.
Density | 1.1±0.1 g/cm3 |
---|---|
Boiling Point | 391.5±17.0 °C at 760 mmHg |
Melting Point | 72-74ºC |
Molecular Formula | C14H16N2O2 |
Molecular Weight | 244.289 |
Flash Point | 190.6±20.9 °C |
Exact Mass | 244.121185 |
PSA | 44.12000 |
LogP | 3.26 |
Vapour Pressure | 0.0±0.9 mmHg at 25°C |
Index of Refraction | 1.562 |
Storage condition | 2-8°C |
Water Solubility | DMSO: >10 mg/mL |
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