Eplerenone
| Price | USD1000.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:9000kg/per week
- Time:2022-05-20
Product Details
- Product NameEplerenone
- CAS No.107724-20-9
- EINECS No.600-850-8
- MFC24H30O6
- MW414.49
- Appearancepowderwhite to beige
- Melting point 241-243°C
- storage temp. Store at RT
- Boiling point 597.9±50.0 °C(Predicted)
- density 1.31±0.1 g/cm3(Predicted)
| Chemical Name | eplerenone |
|---|---|
| Synonyms | epoxymexrenone; Inspra; EplerenoneC24H3006; Elperenone; Epleremone; Expand |
| CAS No. | 107724-20-9 |
| Molecular Formula | C24H30O6 |
| Molecular Weight | 414.49100 |
| PSA | 82.20000 |
| LogP | 3.12450 |
Eplerenone derives its antihypertensive effect by blocking the binding of aldosterone at the mineralocorticoid receptor (MR). The drug, which was previously approved only for the oral treatment of hypertension, is now indicated to improve survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence congestive heart failure (CHF) after an acute myocardial infarction. Aldosterone is a key hormone in the renin-angiotensin-aldosterone system (RAAS), which is of critical importance in the development and progression of hypertension, cardiac remodeling and other cardiovascular diseases. The purpose of RAAS is to control sodium, potassium, and fluid volume balance. Aldosterone binds to MRs in both epithelial (e.g. kidney) and nonepithelial (e.g. heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. The actions of aldosterone can be blocked by spironolactone (Aldactone ?), a relatively nonselective MR antagonist that has been used in clinical practice for many years. Eplerenone, a structural analog of spironolactone, is a highly selective MR antagonist, with significantly lower affinity for other nuclear receptors. It can be prepared by several related ways, with the key step being the introduction of 11-a-hydroxy group on the steroid scaffold via microbiological conversion. The presence of the 11-a-hydroxy group permits the derivation of the epoxy functionality found in eplerenone. Following oral administration, eplerenone is well absorbed and reaches peak plasma concentrations in~2 h. The bioavailability of eplerenone is 98% and it is cleared predominantly by CYP3A4 metabolism, with an elimination half-life of 4-6 h. Steady state is reached within two days. Eplerenone therapy is typically initiated with 25 mg once daily oral dosing and, if tolerated by the patient, titrated to 50 mg once daily. In a clinical study, eplerenone significantly reduced deaths in congestive heart failure patients after a heart attack, above and beyond standard therapy, including ACE inhibitors and β-blockers. The trial in more than 6600 hospitalized patients demonstrated a 15% reduction in the risk of death for eplerenone compared with placebo, in addition to standard treatment. The most commonly reported adverse events associated with eplerenone are hyperkalemia and increased creatine.
Packaging & Shipping
| Quantity(Metric Tons) | 1 - 1 | 2 - 20 | >20 |
| Est. Time(days) | 10 | 25 | To be negotiated |
Company Information
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
Our Services
1.Any inquiry or message will be replied within 12 hours.
2.Professional manufacturer. Welcome to visit our website.
3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
4.Fast delivery.
5.After-sale services
FAQ
Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.
Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.
Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.
Company Profile Introduction
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ，that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
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- Since:2021-03-01
- Address: Room 1810, Future Time Business Building, 121 Zhongshan West Road, Qiaoxi Dist.