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HomecompanyCAS 284461-73-0 Sorafenib tosylate supplier in China
Sorafenib tosylate
Sorafenib tosylate
Sorafenib tosylate
Sorafenib tosylate
Sorafenib tosylate
Sorafenib tosylate

CAS 284461-73-0 Sorafenib tosylate supplier in China

Price USD100.00
Packge 1KG
  • Min. Order:1KG
  • Supply Ability:100000kg
  • Time:2021-12-01

Product Details

  • Product NameSorafenib tosylate
  • CAS No.284461-73-0
  • EINECS No.608-209-4
  • MFC21H16ClF3N4O3
  • MW464.82
  • AppearanceWhite to off-white solid.White to Off-White
  • Melting point 202-204°C
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • Boiling point 523.3±50.0 °C(Predicted)
  • density 1.454±0.06 g/cm3(Predicted)
  • Water Solubility 100μg/L at 20℃

CAS 284461-73-0 Sorafenib tosylate supplier in China


1. details 


Product NameSorafenib Tosylate
AppearanceWhite  powder
Assay99%min, 98.0% --101.0%
TestHPLC 
CertificateISO 9001 
CAS284461-73-0
MFC21H16ClF3N4O3
Storage TemperatureCool Dry Place

 Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.


Functions:

Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.

Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.


2. pictures 




other hotselling products 



Package and shipping 


package: small order in sealed foil bag 

big order in 25kg paper drum or carton box 

shipping : Parcels will be no encounter customs issues such as Mexico ,Spain, UK, Netherlands, USA, Ireland, France, Germany, Brazil, Italy, and many European countries
WE HAVE SPECIAL SHIPPING WAY DDP delivery to your door ,safe and fast 

by express like fedex ,TNT, DHL 

by air to the aiport 

by sea to the seaport 



About our company 


Hebei Crovell Biotech Co,.LTD. is the leading manufacturer for cosmetic materials in China.

Which located in Shijiazhuang, Hebei Province.

We are specialized in pharmaceutical intermediates, veterinary drug intermediates and dyes intermediates,

After ten years development, Hebei Crovell Biotech Co,.LTD. has become a Diversified development company, not only involves in chemicals, but also real estate, clothes, agricultural products and so on.

So far, Hebei Crovell Biotech Co,.LTD. has business in more than 35 countries, most big customers come from Europe and America, because among the suppliers in China, Crovell can always make the product quality best, some of the products from Crovell can reach the purity of 99.9+, such as carbomer. This is the important reason for customers who choosing Crovell.

In future, Hebei Crovell Biotech Co,.LTD. must become to a more important trade bridge for China and foreign countries especially in pharmaceutical industries




FAQ 


Q: How to start orders or make payments?

A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and
we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q: What's your MOQ?

A:For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts
from 100g and 1kg.

Q: Is there a discount?

A: Yes, for larger quantity, we always support with better price.

Q:How do you treat quality complaint?

First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we
will send you free goods for replacement or refund your loss.

Q:How to contact us ?
You can choose your interested products and send inquiry to us.You can dial our telephone directly, you will get our reply.

Company Profile Introduction

Hebei Crovell Biotech Co., Ltd. was founded in 2019 , located in Shijiazhuang city which is the capital of Hebei Province and hub sector among Beijing Tianjin and Hebei and has advantage of convenient transportation . Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.



Our company has strong technical strength, advanced equipment, strict quality management system and high-quality aftersales service, adhers to the "customer first and forge ahead" business philosophy and insists on integrity as the company's survival. All for the customers’ satisfaction, all for the long term healthy development of the enterprise. In the past 2 more years, we have been strictly managing the whole trade process, focusing on every detail, providing customers with all-round services such as product purchase, R & D, quality control, logistics management and so on, and become  reliable cooperation company and partner for our clients. Nowadays We formed large varieties, large scale, complete categories, refined degree, added value and high technology content product chain .There are several series including pharmaceutical products, food grade additives, industrial grade, fertilizer grade and mineral products.


 

Recommended supplier

  • Since:2019-01-04
  • Address: 2-2-1901, Huachenglvzhou 1st Phase. No.169 Shengli Nan Street,Qiaoxi District ,Shijiazhuang city, H
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