large quantity N-Methyl-D-aspartic acid(NMDA)
| Price | USD370.00 |
| Packge | 1KG |
- Min. Order:10IU
- Supply Ability:10
- Time:2020-12-11
Product Details
- Product NameN-Methyl-D-aspartic acid
- CAS No.6384-92-5
- EINECS No.227-012-0
- MFC5H9NO4
- MW147.13
- Appearancesolidwhite
- Water Solubility slightly soluble
- storage temp. Sealed in dry,Room Temperature
- Melting point 187-192 °C
- Boiling point 267.21°C (rough estimate)
- density 1.4285 (rough estimate)
Top quality and High purity N-Methyl-D-aspartic
acid(NMDA) for Nootropics CAS 6384-92-5
Product Name: | N-Methyl-D-aspartic acid |
Synonyms: | n-methylaspartate;n-methyl-d-aspartate;n-methyl-d-asparticaci;H-D-MEASP-OH;H-D-MEASP-OH HCL;[R]-2-[METHYLAMINO]SUCCINIC ACID;N-ALPHA-METHYL-D-ASPARTIC ACID;N-ALPHA-METHYL-D-ASPARTIC ACID HYDROCHLORIDE |
CAS: | 6384-92-5 |
MF: | C5H9NO4 |
MW: | 147.13 |
EINECS: | 227-012-0 |
Mol File: | 6384-92-5.mol |
Description
N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel closely involved in memory, in spatial learning and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.
N-Methyl-D-Aspartic acid (NMDA) is a glutamate-like excitatory substance and is a particularly potent excitant. NMDA binds to NMDA-receptor and interacts with it. This interaction causes a conformational change in the receptor or associated membrane molecules, which opened pores to allow extracellular sodium ions to flow down their electrochemical gradient and depolarise the cell. However, NMDA is proved to be a poor substrate for the uptake transporters, suggesting that the excitatory effect could not be an indirect consequence of glutamate uptake. Besides that, NMDA is found to increase intracellular calcium and release arachidonic acid, both of which generate oxygen radicals, subsequently inducing neuronal death.
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