CAS No.:72-14-0 SULFATHIAZOLE sodium

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Product Details

Product NameSULFATHIAZOLE sodium
CAS No.72-14-0
EINECS No.200-771-5
MFC9H9N3O2S2
MW255.32
InChIKeyJNMRHUJNCSQMMB-UHFFFAOYSA-N
AppearanceneatWhite
Water Solubility Insoluble (<0.1 g/100 mL at 21 ºC)
Melting point 200-202 °C (lit.)
storage temp. 2-8°C
density 1.4629 (rough estimate)
Boiling point 479.5±47.0 °C(Predicted)

Specification

Test items		Standard	Result
Description		White to off- White powder	Conforms
Identification	IR	IR spectrum of sample is the same as working standard	Conforms
	HPLC	HPLC RT of the sample is the same as the working standard	Conforms
Melting point		165.0°C~169.0°C	165.8°C~167.0°C
Optical rotation		-23°~-29°	-27.4°
Loss on drying		NMT 1.0 %	0.17%
Residue on ignition		NMT 0.1 %	0.03%
Heavy metals		NMT 20ppm	Conforms
Related substances
Impurity A		NMT 0.1 %	Not detected
Impurity B		NMT 0.1 %	Not detected
Impurity C		NMT 0.1 %	0.02%
Single impurity		NMT 0.2 %	0.17%
Total impurity		NMT 1.0 %	0.60%
Assay		NLT 99.0%	99.0%

Function

Posaconazole is a broadspectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14ademethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membranebound proteins.Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14a demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changesthe fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.

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Company Profile

Welcome to Hebei Guanlang Biotechnology Co.Ltd (Guanlang)

Guanlang is a fast growing intermediates company,Which located in Shijiazhuang,Hebei Province.Our main product is chlorine dioxide, Sodium dichloroisocyanurate(sdic or nadcc) ANDTrichloroisocyanuric acid (TCCA)for water treatment.We also supply raw materials for detergent and hand sanitizer products,such as carbopol 940,carbopol stock solution,Hydroxypropyl methyl cellulose (HPMC) and so on.

Guanlang also supply various industrial chemicals for customers, such as citric acid,potassium chloride etc.After ten years development,Crovell has become a Diversified development company,not only involves in chemicals, but also real estate ,agricultural products and so on.So far, Guanlang has usiness in more than 35 countries,most big customers come from europe and America, because among the suppliers in China.

Guanlang can always make the product quality best, some of the products from Guanlang.This is the important reason for customers who choosing Crovell.In future, Guanlang must become to a more important trade bridge for china and foreign countries especially in pharmaceutical industries.

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why choose our company

1. quality

our products meet msds safe standard and we have iso and other certificate so yan can get high quality products from our company.
2. price

we are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.

3.packing

we can do according to the customers' request.

4.transport

ems,dhl, tnt, ups ,fedex, by air, by sea
dhl express, fedex and ems for quantity less than 50kg, usually called as ddu service;
sea shipping for quantity over 500kg; and air shipping is available for 50kg above;
for high value products, please select air shipping and dhl express for safe;

5.service

we offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes
us able to offer you one-stop service from the order to the products transported to your hand.

we will try our best to satisfied you.
1. tailor-made for every customers.
2. third-party test for the products you demand.
3. test your counter-samples and produce them for you.
4. best discount for old customers.

Company Profile Introduction

Hebei Guanlang Biotechnology Co., Ltd. was founded in 2007, located in Shijiazhuang City,
which is the capital of Hebei Province and hub sector among Beijing, Tianjin, and Hebei.
We have the advantage of convenient transportation.
Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.

In recent five years, the company has implemented the strategy of "going out" vigorously.
We has established our branches in Hubei China, Vietnam and Mexico, making our market and sales network more and more perfect.
Our company will continue to adhere to the strategic positioning of fine chemical industry in the future and competition ideas of irreplaceable product differentiation,
and strive to become to the leading of Chinese chemical industry.

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2024-01-27