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donepezil
donepezil
donepezil

donepezil

Price USD800.00
Packge 1KG
  • Min. Order:1KG
  • Supply Ability:30tons/week
  • Time:2021-07-09

Product Details

  • Product Namedonepezil
  • CAS No.120014-06-4
  • EINECS No.601-651-9
  • MFC24H29NO3
  • MW379.49
  • AppearanceSolidWhite to Off-White
  • Melting point 207°C
  • Water Solubility 2.931 mg/L
  • Boiling point 527.9±50.0 °C(Predicted)
  • density 1.141±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,Room Temperature

Product description 

Product Name: Donepezil
Synonyms: DONEPEZIL;AKOS 226-23;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;n-1-one;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one
CAS: 120014-06-4
MF: C24H29NO3
MW: 379.49
EINECS: 601-651-9
Product Categories: Isotope;Other APIs
Mol File: 120014-06-4.mol
Donepezil Chemical Properties
Melting point  207°C
Boiling point  527.9±50.0 °C(Predicted)
density  1.141±0.06 g/cm3(Predicted)
pka 8.84±0.10(Predicted)
Water Solubility  2.931 mg/L
CAS DataBase Reference 120014-06-4(CAS DataBase Reference)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37/39
RIDADR  UN 2811
HS Code  29333990
 
Donepezil Usage And Synthesis
Description Donepezil is another "nonclassic," centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.
Uses Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer's disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]
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Our Advantage 
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
 
Shipping
1. By Courier: Fedex, EMS, DHL, TNT, UPS, etc. 
2. By air, airport to airport
3. By sea
 
Contact us 
Hebei Xibaijie Biotechnology Co.,Ltd 
Website :http://www.hbxibaijie.com     
Whatsapp:+86 152 3210 3582
Wechat:Hebeixibaijiesonya

Company Profile Introduction

Company profile Hebei Xibaijie Biotechnology Co., Ltd has a registered capital of 3 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. Now we have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. Also we have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit. After many years of efforts, we have established stable and friendly business relations with many of European and American pharmaceutical companies, multinational chemical companies and importers.At home and many production plants and research and development units have established long - term commission processing and production relations.We have a number of laboratories specializing in technology development and custom synthesis, as well as some production bases, mainly in hebei, dalian, jiangsu and guangzhou. Our company possesses the right of self-support import & export, a strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards. We put the quality management as the focus of enterprise management, to customer satisfaction for the purpose of the company, in order to ensure the quality of each batch of products to meet customer demand.We by strengthening employee training, improve the detection technology, perfect detection index to improve every aspect of quality control, improve the quality of the products.
  • Since:2019-07-05
  • Address: Federation business plaza, qiaoxi district, shijiazhuang city, hebei province
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