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HomeProduct name listZK118182 isopropyl ester

ZK118182 isopropyl ester

ZK118182 isopropyl ester Structural

What is ZK118182 isopropyl ester?

Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

What are the applications of Application

ZK118182 isopropyl ester is a PG analog that shows potent DP-agonist activity

Properties of ZK118182 isopropyl ester

Boiling point: 553.1±50.0 °C(Predicted)
Density  1.14±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka 14.22±0.70(Predicted)

Safety information for ZK118182 isopropyl ester

Computed Descriptors for ZK118182 isopropyl ester

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