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HomeProduct name listZ-Lys(Z)-OH

Z-Lys(Z)-OH

Synonym(s):N,N′-Di-Cbz-L-lysine;Nα,Nε-Di-Z-L-lysine

  • CAS NO.:405-39-0
  • Empirical Formula: C22H26N2O6
  • Molecular Weight: 414.45
  • MDL number: MFCD00037822
  • EINECS: 206-971-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-03-28 11:36:32
Z-Lys(Z)-OH  Structural

What is Z-Lys(Z)-OH ?

Chemical properties

White Solid

The Uses of Z-Lys(Z)-OH

Protected L-lysine

Definition

Z-Lys(Z)-OH is a lysine derivative.

Synthesis

A 250 mL three-necked flask was loaded consecutively with water (20 mL), 1,4-dioxane (20 mL), and L-lysine (2.1 g, 14.4 mmol). The mixture was stirred until complete dissolution. The pH was adjusted to about 10.5 by the addition of 30% NaOH. Benzyl chloroformate (5.2 g, 30.6 mmol) was added while maintaining the pH at about 1011 by adding at the same time 30% NaOH. At the end of the addition, the reaction was stirred at 20° C. for about 1 hour. The pH was adjusted to 5 with 37% HCl. Ethyl acetate (30 mL) was added and the pH was adjusted to 1 with 37% HCl. The mixture was stirred at room temperature for about 30 minutes, the organic layer was separated and the aqueous layer was extracted with ethyl acetate (20 mL). The combined organic layer was washed with brine (30 mL) and dried over Na2SO4. Then, the solvent was evaporated to yield Z-Lys(Z)-OH as a yellowish oil (6.0 g, 99%).

Properties of Z-Lys(Z)-OH

Melting point: 76-78°C
Boiling point: 659.0±55.0 °C(Predicted)
Density  1.238±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 3.97±0.21(Predicted)
color  White to Off-White
BRN  1897206
CAS DataBase Reference 405-39-0(CAS DataBase Reference)

Safety information for Z-Lys(Z)-OH

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Z-Lys(Z)-OH

InChIKey BLZXFNUZFTZCFD-IBGZPJMESA-N
SMILES C(O)(=O)[C@H](CCCCNC(OCC1=CC=CC=C1)=O)NC(OCC1=CC=CC=C1)=O

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