Z-FL-COCHO

Synonym(s):(3R,4S)-4-(4-Fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate;LY 3000328;LY-3000328;N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide

CAS NO.：1373215-15-6
Empirical Formula: C25H29FN4O5
Molecular Weight: 484.52
MDL number: MFCD04974155
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-11 20:33:26

What is Z-FL-COCHO?

Description

LY3000328 is a potent cathepsin S inhibitor (IC₅₀ = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC₅₀s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.

The Uses of Z-FL-COCHO

LY 3000328 is a cathepsin S inhibitor for treatment of abdominal aortic aneurysm. Further provides methods for treating plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a disclosed compound.

References

[1] wiener jj, sun s, thurmond rl. recent advances in the design of cathepsin s inhibitors. curr top med chem. 2010;10(7):717-32.
[2] lee-dutra a, wiener dk, sun s. cathepsin s inhibitors: 2004-2010. expert opin ther pat. 2011;21(3):311-37.

Properties of Z-FL-COCHO

Boiling point:	701.6±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥24.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	Powder
pka	12.50±0.46(Predicted)
color	White to off-white

Safety information for Z-FL-COCHO

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Z-FL-COCHO

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