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HomeProduct name listYM 26734

YM 26734

Synonym(s):1,1′-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis1-dodecanone

YM 26734 Structural

What is YM 26734?

The Uses of YM 26734

YM-26734 is a derivative of a compound isolated from the fruit of H. amygdaline that competitively inhibits rabbit platelet sPLA2 which is a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions.

What are the applications of Application

YM 26734 is a competitive inhibitor of secretory phospholipase A2 (PLA2)

Biological Activity

Competitive inhibitor of secretory phospholipase A 2 (sPLA 2 ) that exhibits a broad inhibitory profile to several sPLA 2 s (IC 50 values are 0.2, 1, 1, 1 and 3 μ M for sPLA 2 -X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA 2 -IIF and no activity at cytosolic PLA 2 , cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

storage

Store at -20°C

Properties of YM 26734

storage temp.  Store at -20°C
solubility  Soluble to 100 mM in DMSO and to 100 mM in ethanol
form  Powder

Safety information for YM 26734

Computed Descriptors for YM 26734

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