YM 26734
Synonym(s):1,1′-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis1-dodecanone
- CAS NO.:144337-18-8
- Empirical Formula: C45H62O8
- Molecular Weight: 730.97
- MDL number: MFCD00918068
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is YM 26734?
The Uses of YM 26734
YM-26734 is a derivative of a compound isolated from the fruit of H. amygdaline that competitively inhibits rabbit platelet sPLA2 which is a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions.
What are the applications of Application
YM 26734 is a competitive inhibitor of secretory phospholipase A2 (PLA2)
Biological Activity
Competitive inhibitor of secretory phospholipase A 2 (sPLA 2 ) that exhibits a broad inhibitory profile to several sPLA 2 s (IC 50 values are 0.2, 1, 1, 1 and 3 μ M for sPLA 2 -X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA 2 -IIF and no activity at cytosolic PLA 2 , cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
storage
Store at -20°C
Properties of YM 26734
storage temp. | Store at -20°C |
solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
form | Powder |
Safety information for YM 26734
Computed Descriptors for YM 26734
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 2,2-diethoxyethanethioamide Tubulysin I Tubulysin D Tubulysin A Tubulysin G Diethyl Aluminium Cyanide (1.0 M in Toluene) Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Methyl 4-amino-3-(dihexylamino)benzoate 3-Morpholino-5,6-dihydropyridin-2(1H)-one 4-(Azidomethyl)-3-chloropyridine (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 3,3,6,6-Tetramethylcyclohexane-1,2-dione 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 1,3,5-Trimethyl-1,4-cyclohexadieneRelated products of tetrahydrofuran
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