XENIN 25
Synonym(s):alpha coat protein;coatomer protein complex, subunit alpha;FLJ26320;HEP-COP;xenin
- Empirical Formula: C139H224N38O32S
- Molecular Weight: 2971.57
- MDL number: MFCD00214654
- Update Date: 2023-04-23 13:52:06
What is XENIN 25?
Description
A 25-aa peptide with six C-terminal aa in common with the amphibian octapeptide xenopsin was identified from the human gastric mucosa in 1992 and named xenin. Xen was identified in various mammals, including dogs, pigs, rats, guinea pigs, and rabbits, in 1995.
Clinical Use
A novel hybrid peptide, exendin-4/gastrin/Xen-8, was developed to improve the metabolic status in obese diabetic mice.21 In addition, Xen-8, a fragment of Xen-25, possesses the same biological functions as Xen-25. Thus, not only Xen-25, but also Xen-8 and the hybrid peptide are expected to exert beneficial metabolic effects in relation to new therapeutic approaches for diabetes and obesity.
Structure and conformation
Xen is highly conserved across species from insects to mammals. It is cleaved from the N-terminus of its precursor, coatomer protein α (COPA), by an aspartic protease, presumably cathepsin E. Xen has close structural similarities to neurotensin, and is a part of the neurotensin/xenopsin/xenin family along with neuromedin N and kinetensin/NRP. Xen consists of 25 aa, and the putative aa sequence of Xen based on the COPA gene database is evolutionarily conserved from yeast to mammals. The aa sequence of Xen is identical in the acorn worm, salmon, wild turkey, Chinese hamster, mouse, bull, rhesus macaque, and human. The bioactive C-terminal octapeptide of Xen, termed Xen-8, is a natural metabolite that circulates in the plasma.
Properties of XENIN 25
storage temp. | −20°C |
solubility | H2O: soluble |
Safety information for XENIN 25
Computed Descriptors for XENIN 25
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin C Tubulysin B Tubulysin I Potassium HMDS (1.0 M in THF) 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2,2-Difluoropropanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 3-(S)-(+)- (1-Cyano-1,1- diphenylmethyl)- 1-tosylpyrrolidine 4-(2-fluoro-4- nitrophenyl) thiomorpholine Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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