VICRIVIROC MALEATE
- CAS NO.：599179-03-0
- Empirical Formula: C32H42F3N5O6
- Molecular Weight: 649.7009896
- MDL number: MFCD09833218
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 11:39:26
What is VICRIVIROC MALEATE?
Description
Vicriviroc is a chemokine (C-C motif) receptor 5 (CCR5) antagonist (Ki = 2.5 nM). It selectively inhibits CCR5 over M1 and M2 muscarinic acetylcholine receptors (Kis = >10,000 nM for both) and human-ether-a-go-go (hERG) potassium channels (IC50 = 5.8 μM). Vicriviroc decreases chemotaxis induced by chemokine (C-C motif) ligand 3 (CCL3) in Ba/F3 cells expressing recombinant human CCR5 with an IC50 value of 0.91 nM. It inhibits the replication of 30 R5-tropic HIV-1 clinical isolates in peripheral blood mononuclear cells (PBMCs; EC50s = 0.04-1.4 nM) and reduces viral entry of seven drug-resistant strains of HIV-1 in U87 cells expressing CD4 and CCR5 (EC50s = 8.7-32.9 nM).
The Uses of VICRIVIROC MALEATE
Antiviral, CCR5 antagonist, treatment of autoimmune conditions.
Properties of VICRIVIROC MALEATE
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (76.96 mM; Need ultrasonic)H2O : 25 mg/mL (38.48 mM; Need ultrasonic and warming) |
| form | Powder |
| color | White to off-white |
Safety information for VICRIVIROC MALEATE
Computed Descriptors for VICRIVIROC MALEATE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION INOSITOL PANTOPRAZOLE SODIUM SESQUIHYDRATE Metformin FLUCLOXACILLIN SODIUM STERILE NIMESULIDE BP ZONISAMIDE 1,1-Dimethylethyl 4-(2-azidoacetyl)-1-piperidinecarboxylate 2-Bromo-1-(bromomethyl)-3-iodo-5-nitrobenzene 1,2-Dibromo-3-(bromomethyl)-5-nitrobenzene 2-Cyano-5-pyrimidineacetonitrile 7-Fluoro-4-cinnolinamine 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzeneRelated products of tetrahydrofuran
![(4,6-dimethylpyrimidin-5-yl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluor omethyl)phenyl]ethyl]-3-methyl-piperazin-1-yl]-4-methyl-1-piperidyl]me thanone](https://img.chemicalbook.in/CAS/20180808/GIF/306296-47-9.gif)
You may like
-
Vicriviroc Maleate CAS 599179-03-0View Details
599179-03-0 -
1823754-06-8 98%View Details
1823754-06-8 -
1935373-20-8 3-(Bromomethyl)-6-fluoro-1,2-benzenediamine 98%View Details
1935373-20-8 -
2-Chloro-5-(iodomethyl)pyrimidine 2268818-88-6 98%View Details
2268818-88-6 -
2092793-98-9 98%View Details
2092793-98-9 -
1360944-55-3 7-Methoxy-1H-indol-5-amine 98%View Details
1360944-55-3 -
2090480-14-9 98%View Details
2090480-14-9 -
1-Methyl 2-bromo-5-[(1-carboxy-1-methylethyl)amino]benzoate 1651844-56-2 98%View Details
1651844-56-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.