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HomeProduct name listVanillyl alcohol

Vanillyl alcohol

Synonym(s):4-Hydroxy-3-methoxybenzyl alcohol;NSC 3993;Vanillyl alcohol

  • CAS NO.:498-00-0
  • Empirical Formula: C8H10O3
  • Molecular Weight: 154.16
  • MDL number: MFCD00004659
  • EINECS: 207-852-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
Vanillyl alcohol Structural

What is Vanillyl alcohol?

Description

4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.

Chemical properties

crystalline white to off-white powder

Chemical properties

Vanillyl alcohol is a lignin derived aromatic diol. It has a mild, sweet, balsamic, vanilla-like odor.  It has a potential for the production of renewable epoxy thermosets. A bio-based bisphenolic analogue, bisguaiacol, was synthesized via the electrophilic aromatic condensation of vanillyl alcohol and guaiacol. From this, the diglycidyl ether of bisguaiacol was prepared. Further, three single aromatic diglycidyl ethers were synthesized from vanillyl alcohol, gastrodigenin, and hydroquinone. 

The Uses of Vanillyl alcohol

Used as a flavoring agent. Other possible uses, vanilla, coconut, cream and other dairy nuances, coumarin.

Definition

ChEBI: Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols.

Taste threshold values

Sweet, creamy and milky with a slightly powdery mouthfeel.

General Description

Vanillyl alcohol belongs to the phenolic group of compounds which are widely used as oxidants in food products.

Biochem/physiol Actions

Odor at 1.0%: sweet creamy, phenolic, vanilla and coconut-like with slight brown and coumarinic nuances.

Synthesis

Vanillyl alcohol is prepared from Vanillin by hydrogenation in presence of Platinum black.

References

Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.

Properties of Vanillyl alcohol

Melting point: 110-117 °C (lit.)
Boiling point: 237.52°C (rough estimate)
Density  1.1690 (rough estimate)
refractive index  1.4620 (estimate)
FEMA  3737 | VANILLYL ALCOHOL
storage temp.  Inert atmosphere,Room Temperature
solubility  soluble in Methanol
form  Fine Crystalline Powder
pka 9.75±0.18(Predicted)
color  Off-white to beige
Odor at 100.00 %. sweet creamy vanilla caramellic coconut graham cracker tonka milky powdery
Water Solubility  Soluble in 95% ethanol (5 %), water, and oils.
JECFA Number 886
BRN  1910044
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference 498-00-0(CAS DataBase Reference)
NIST Chemistry Reference 4-Hydroxy-3-methoxybenzyl alcohol(498-00-0)

Safety information for Vanillyl alcohol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Vanillyl alcohol

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