V-9-M cholecystokinin nonapeptide
- CAS NO.:99291-20-0
- Empirical Formula: C42H69N9O14S
- Molecular Weight: 956.11
- MDL number: MFCD00076493
- EINECS: 200-001-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:07
What is V-9-M cholecystokinin nonapeptide?
Description
V-9-M Cholecystokinin nonapeptide is a glucagon-like peptide receptor agonist, namely GLP-1 receptor agonist. Human GLP-1 is a peptide hormone secreted by intestinal L cells.
The Uses of V-9-M cholecystokinin nonapeptide
V-9-M cholecystokinin nonapeptide belongs to the glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) class of hypoglycemic drugs, which increase insulin secretion in a glucose-dependent manner and inhibit glucagon secretion , and can promote gastric emptying, centrally suppress appetite, reduce food intake, and then reduce glucose absorption to achieve the effect of lowering blood sugar.
General Description
V-9-M cholecystokinin nonapeptide, also known as Cholecystokinin Precursor (24-32) (rat), is a precursor compound of cholecystokinin (CCK) that is expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin (CCK) is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion, as well as a neurotransmitter. It can be extracted from the small intestine of dogs and cats and causes gallbladder contractions.
Mechanism of action
V-9-M cholecystokinin nonapeptide's mechanism of action is to act on islet beta cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of islet beta cells, increase the number of islet beta cells, and protect islet function. It can also act on islet alpha cells, inhibit the release of glucagon, and reduce the release of hepatic glucose.
Solubility in organics
V-9-M cholecystokinin nonapeptide is soluble in DMSO solution, the reference solubility range is shown below:
storage
Store at low temperatures to avoid moisture:
Powder: -20°C, 3 years.
Solvents: -80°C, 2 years.
References
1. Takashima A, Itoh S. Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat. Can J Physiol Pharmacol. 1989 Mar;67(3):223-7. DOI: 10.1016/0301-0082(90)90035-F
2. Cholecytokinin (CCK) gene-related peptides: distribution and characterization of immunoreactive pro-CCK and an amino-terminal pro-CCK fragment in rat brain. DOI: 10.1016/0006-8993(85)90813-3
3. Cao G, Beinfeld MC. Calcium-dependent pro-cholecystokinin V-9-M immunoreactive peptide release from rat brain slices and CCK-secreting rat medullary thyroid carcinoma cells in culture. Peptides. 1992 Nov-Dec;13(6):1087-90. DOI: 10.1016/0196-9781(92)90011-Q
Properties of V-9-M cholecystokinin nonapeptide
Boiling point: | 1350.7±65.0 °C(Predicted) |
Density | 1.306±0.06 g/cm3(Predicted) |
pka | 3.51±0.10(Predicted) |
form | Solid |
color | White to off-white |
Safety information for V-9-M cholecystokinin nonapeptide
Computed Descriptors for V-9-M cholecystokinin nonapeptide
InChIKey | AIKMAJWJXJPJNB-HNRKYVDVNA-N |
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin F Tubulysin G Tubulysin D Potassium HMDS (1.0 M in THF) 3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Aminotetrahydropyran hydrochloride 3-FLUOROPYRROLIDINE HYDROCHLORIDE (S)-3-Aminobutanenitrile hydrochloride 4-Methylenepiperidine HCl (R)-1-BOC-3-FLUORO PYRROLIDINE 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone (6-Nitro-2,3- dichlorobenzylamino) acetic acid ethylester.HCl 5-(piperazin-1-yl) benzofuran-2- carboxamide Lubiprostone Magnesium Trisilicate Latanoprostene Bunod 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid (2R,3S)-2-Azido-3-methylpentanoic acid (R)-methyl 2-isocyano-3-(tritylthio)propanoate Megestrol Acetate EP Impurity D FUSIDIC ACID EP IMPURITY I / FUSIDIC ACID BP IMPURITY I / FUS 16-EPI-DEACETYL FUSIDIC ACIDRelated products of tetrahydrofuran
You may like
-
ethyl 2-formylthiazole-4-carboxylate 73956-17-9 99%View Details
73956-17-9 -
Tubulysin D 99%View Details
309935-57-7 -
Methyl (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate 58885-35-1 99%View Details
58885-35-1 -
(R)-methyl 2-isocyano-3-(tritylthio)propanoate 99%View Details
-
Tubulysin G 99%View Details
799822-08-5 -
Tubulysin C 205304-88-7 99%View Details
205304-88-7 -
205304-87-6 Tubulysin B 99%View Details
205304-87-6 -
205304-86-5 99%View Details
205304-86-5