UROCORTIN (HUMAN)
Synonym(s):UCN;Urocortin
- CAS NO.：176591-49-4
- Empirical Formula: C206H338F3N63O66
- Molecular Weight: 4810.2656296
- MDL number: MFCD00802621
- Update Date: 2024-10-23 13:36:13
What is UROCORTIN (HUMAN)?
The Uses of UROCORTIN (HUMAN)
Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.
Biochem/physiol Actions
Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Clinical Use
Ucn1 levels are high in the synovial fluid of patients with rheumatoid arthritis. Ucn1 has been linked to a reduction in inflammation and bone erosion in a mouse model of rheumatoid arthritis.
storage
Store at -20°C
Properties of UROCORTIN (HUMAN)
| storage temp. | -20°C |
| form | powder |
| color | White to off-white |
| Water Solubility | Soluble to 1 mg/ml in water |
Safety information for UROCORTIN (HUMAN)
Computed Descriptors for UROCORTIN (HUMAN)
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