URIDINE 5'-TRIPHOSPHATE TRIS SALT
Synonym(s):UTP
- CAS NO.:108321-53-5
- Empirical Formula: C13H26N3O18P3
- Molecular Weight: 605.28
- MDL number: MFCD00058360
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is URIDINE 5'-TRIPHOSPHATE TRIS SALT?
The Uses of URIDINE 5'-TRIPHOSPHATE TRIS SALT
Uridine 5''-Triphosphate Tris Salt is a polyphosphate analogue of the nucleoside Uridine used in the preparation of potent and selective agonists at the G-protein-coupled P2Y receptors.
The Uses of URIDINE 5'-TRIPHOSPHATE TRIS SALT
Uridine 5′-triphosphate tris salt has been used:
- to investigate its activation potential on the purinergic?P2Y2 Receptor in THP1 monocytes
- as a component of non-radioactive nucleoside triphosphate solution used in in vitro RNA polymerase assay
- as a P2Y2 agonist in human embryonic kidney cells (HEK293T) in dynamic mass redistribution (DMR) assays
What are the applications of Application
Uridine 5′-triphosphate tris salt is a P2Y receptor agonist
Biochem/physiol Actions
Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic?(P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway.
Properties of URIDINE 5'-TRIPHOSPHATE TRIS SALT
storage temp. | -20°C |
solubility | H2O: soluble50mg/mL, clear, colorless |
Safety information for URIDINE 5'-TRIPHOSPHATE TRIS SALT
Computed Descriptors for URIDINE 5'-TRIPHOSPHATE TRIS SALT
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