UK-371804

CAS NO.：256477-09-5
Empirical Formula: C14H16ClN5O4S
Molecular Weight: 385.83
MDL number: MFCD30749185
Update Date: 2024-11-19 20:33:22

What is UK-371804?

Description

UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.

References

http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.

Properties of UK-371804

storage temp.	Store at -20°C
solubility	DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
form	A crystalline solid
color	White to off-white
CAS DataBase Reference	256477-09-5

Safety information for UK-371804

Computed Descriptors for UK-371804

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