Tyr-α-CGRP (human)
- CAS NO.:124756-98-5
- Empirical Formula: C174H277F3N52O53S2
- Molecular Weight: 4066.5029896
- Update Date: 2023-05-21 10:59:17
What is Tyr-α-CGRP (human)?
Description
Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; ).1 It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).2 Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).1 It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).3
References
1. Poyner, D.R., Andrew, D.P., Brown, D., et al. Pharmacological characterization of a receptor for calcitonin gene-
2. Hay, D.L., Christopoulos, G., Christopoulos, A., et al. Pharmacological discrimination of calcitonin receptor: Receptor activity-
3. Dennis, T., Fournier, A., St. Pierre, S., et al. Structure-
Properties of Tyr-α-CGRP (human)
storage temp. | Store at -20°C |
solubility | Water: 1 mg/ml |
form | A lyophilized powder |
Safety information for Tyr-α-CGRP (human)
Computed Descriptors for Tyr-α-CGRP (human)
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