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HomeProduct name listTyr-α-CGRP (human)

Tyr-α-CGRP (human)

  • CAS NO.:124756-98-5
  • Empirical Formula: C174H277F3N52O53S2
  • Molecular Weight: 4066.5029896
  • Update Date: 2023-05-21 10:59:17
Tyr-α-CGRP (human) Structural

What is Tyr-α-CGRP (human)?

Description

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; ).1 It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).2 Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).1 It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).3

References

1. Poyner, D.R., Andrew, D.P., Brown, D., et al. Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes Br. J. Pharmacol. 105(2),441-447(1992).
2. Hay, D.L., Christopoulos, G., Christopoulos, A., et al. Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes Mol. Pharmacol. 67(5),1655-1665(2005).
3. Dennis, T., Fournier, A., St. Pierre, S., et al. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity J. Pharmacol. Exp. Ther. 251(2),718-725(1989).

Properties of Tyr-α-CGRP (human)

storage temp.  Store at -20°C
solubility  Water: 1 mg/ml
form  A lyophilized powder

Safety information for Tyr-α-CGRP (human)

Computed Descriptors for Tyr-α-CGRP (human)

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