Tubulysin A,TubA
Synonym(s):TubA
- CAS NO.：205304-86-5
- Empirical Formula: C43H65N5O10S
- Molecular Weight: 844.07
- MDL number: MFCD12912448
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:20
What is Tubulysin A,TubA?
The Uses of Tubulysin A,TubA
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
Definition
ChEBI: Tubulysin A is a diester and a carboxylic acid.
Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
Properties of Tubulysin A,TubA
| Melting point: | 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
| Boiling point: | 979.9±65.0 °C(Predicted) |
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | organic solvents: soluble |
| form | film |
| pka | 4.52±0.23(Predicted) |
| color | colorless or white |
Safety information for Tubulysin A,TubA
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tubulysin A,TubA
Tubulysin A,TubA manufacturer
Ajitha Prodrug India Pvt Ltd
1Y
Phone:+91-9845915533
Whatsapp: +91- 9845915533
product: 205304-86-5 99%
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