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HomeProduct name listTubulysin A,TubA

Tubulysin A,TubA

Synonym(s):TubA

Tubulysin A,TubA Structural

What is Tubulysin A,TubA?

The Uses of Tubulysin A,TubA

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

Definition

ChEBI: Tubulysin A is a diester and a carboxylic acid.

Biochem/physiol Actions

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

Properties of Tubulysin A,TubA

Melting point: 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point: 979.9±65.0 °C(Predicted)
Density  1.195±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  organic solvents: soluble
form  film
pka 4.52±0.23(Predicted)
color  colorless or white

Safety information for Tubulysin A,TubA

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H311:Acute toxicity,dermal
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H331:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P311:Call a POISON CENTER or doctor/physician.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Tubulysin A,TubA

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