(TRIMETHYLSILYL)ACETIC ACID
- CAS NO.：2345-38-2
- Empirical Formula: C5H12O2Si
- Molecular Weight: 132.23
- MDL number: MFCD00042651
- EINECS: 219-067-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (TRIMETHYLSILYL)ACETIC ACID?
Physical properties
mp 40 °C.
The Uses of (TRIMETHYLSILYL)ACETIC ACID
(Trimethylsilyl)acetic acid may be used in chemical synthesis.
The Uses of (TRIMETHYLSILYL)ACETIC ACID
Trimethylsilylacetic Acid is a valuable reagent used in preparation of α,β-unsaturated carboxylic acids and α-trimethylsilylbutyrolactones,
Preparation
Obtained from the reaction of trimethylsilylmethylmagnesium chloride with carbon dioxide;3 can also be prepared by reaction of acetic acid with 2 equiv of lithium diisopropylamide, followed by chlorotrimethylsilane and hydrolysis.
Properties of (TRIMETHYLSILYL)ACETIC ACID
| Melting point: | 39-42 °C(lit.) |
| Boiling point: | 90-95°C 10mm |
| Density | 0.8830 (estimate) |
| Flash point: | 203 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Sol ethereal solvents. |
| form | solid |
| pka | 5.23±0.10(Predicted) |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| Sensitive | Moisture Sensitive |
| BRN | 1679394 |
| CAS DataBase Reference | 2345-38-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, (trimethylsilyl)-(2345-38-2) |
| EPA Substance Registry System | Acetic acid, (trimethylsilyl)- (2345-38-2) |
Safety information for (TRIMETHYLSILYL)ACETIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (TRIMETHYLSILYL)ACETIC ACID
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ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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