(TRIMETHYLSILYL)ACETIC ACID
- CAS NO.:2345-38-2
- Empirical Formula: C5H12O2Si
- Molecular Weight: 132.23
- MDL number: MFCD00042651
- EINECS: 219-067-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (TRIMETHYLSILYL)ACETIC ACID?
Physical properties
mp 40 °C.
The Uses of (TRIMETHYLSILYL)ACETIC ACID
(Trimethylsilyl)acetic acid may be used in chemical synthesis.
The Uses of (TRIMETHYLSILYL)ACETIC ACID
Trimethylsilylacetic Acid is a valuable reagent used in preparation of α,β-unsaturated carboxylic acids and α-trimethylsilylbutyrolactones,
Preparation
Obtained from the reaction of trimethylsilylmethylmagnesium chloride with carbon dioxide;3 can also be prepared by reaction of acetic acid with 2 equiv of lithium diisopropylamide, followed by chlorotrimethylsilane and hydrolysis.
Properties of (TRIMETHYLSILYL)ACETIC ACID
Melting point: | 39-42 °C(lit.) |
Boiling point: | 90-95°C 10mm |
Density | 0.8830 (estimate) |
Flash point: | 203 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | Sol ethereal solvents. |
form | solid |
pka | 5.23±0.10(Predicted) |
Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
Sensitive | Moisture Sensitive |
BRN | 1679394 |
CAS DataBase Reference | 2345-38-2(CAS DataBase Reference) |
NIST Chemistry Reference | Acetic acid, (trimethylsilyl)-(2345-38-2) |
EPA Substance Registry System | Acetic acid, (trimethylsilyl)- (2345-38-2) |
Safety information for (TRIMETHYLSILYL)ACETIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (TRIMETHYLSILYL)ACETIC ACID
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
(Trimethylsilyl)acetic acid 1,1-dimethylethyl ester
2-(Trimethylsilyl)acetic acid methyl ester
ETHYL 2-BROMO-2-(1,1,1-TRIMETHYLSILYL)ACETATE
METHYL (1-TRIMETHYLSILYL)ACRYLATE
(-)-BENZYLMETHYLPHENYLSILYLACETIC ACID
TRIMETHYLSILYL (TRIMETHYLSILYL)ACETATE
2-(Trimethylsilyl)acetic acid ethyl ester,(TRIMETHYLSILYL)ACETIC ACID ETHYL ESTER,ETSA~(Trimethylsilyl)acetic acid ethyl ester
2,2-DIFLUORO-2-(TRIMETHYLSILYL)ACETIC ACID PROPYL ESTER
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