Trimethyl orthobenzoate
- CAS NO.：707-07-3
- Empirical Formula: C10H14O3
- Molecular Weight: 182.22
- MDL number: MFCD00008474
- EINECS: 211-897-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:32
What is Trimethyl orthobenzoate?
Chemical properties
clear colorless liquid
The Uses of Trimethyl orthobenzoate
Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067
General Description
Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.
Properties of Trimethyl orthobenzoate
| Boiling point: | 87-88 °C/7 mmHg (lit.) |
| Density | 1.061 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 180 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in organic solvents. |
| form | Liquid |
| color | Clear colorless |
| Sensitive | Moisture Sensitive |
| BRN | 777623 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 707-07-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, (trimethoxymethyl)-(707-07-3) |
| EPA Substance Registry System | Benzene, (trimethoxymethyl)- (707-07-3) |
Safety information for Trimethyl orthobenzoate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trimethyl orthobenzoate
| InChIKey | IECKAVQTURBPON-UHFFFAOYSA-N |
Trimethyl orthobenzoate manufacturer
Syn Finechem Laboratories Pvt Ltd.
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Phone:+91-9848230784
Whatsapp: +91 9848230784
product: Trimethyl orthobenzoate 707-07-3 98%
BASR Fine Chemicals Pvt. Ltd.
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Phone:+91-9848230391
Whatsapp: +91-9848230391
product: 707-07-3 Trimethyl orthobenzoate 98%
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