Triisopropylsilane

Chemical properties

Clear colorless liquid

The Uses of Triisopropylsilane

Triisopropylsilane is used as a protecting group in peptide synthesis and is also used as a reducing agent for the selective reduction of anomeric C-phenyl ketals. It is used in the selective silylation of primary hydroxyl groups without affecting the secondary hydroxyl group. It is used in the preparation of anti-1,2-diols catalyzed by a Ni(O) N-heterocyclic carbine complex with high diastereoselectivity.

The Uses of Triisopropylsilane

The bulky isopropyl groups (vs. ethyl) allow for more selective reductions, e.g., beta-selective reduction of anomeric C-phenyl ketals, but do not diminish their activity (e.g. in the copper triflate catalyzed reductive etherification of trimethylsilyl ethers).

The Uses of Triisopropylsilane

Selective silylation of primary hydroxy groups in the presence of secondary alcohol.

What are the applications of Application

Triisopropylsilane is a highly selective reducing agent which can be used to prepare anti-1,2-diols.

What are the applications of Application

Very sterically-hindered silane. Used as a cation scavenger in the deprotection of peptides.