Trifluorothymine
Synonym(s):5-Trifluoromethyluracil
- CAS NO.：54-20-6
- Empirical Formula: C5H3F3N2O2
- Molecular Weight: 180.08
- MDL number: MFCD00006024
- EINECS: 200-197-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-22 13:59:06
What is Trifluorothymine?
Chemical properties
White to faintly yellow crystalline powder
The Uses of Trifluorothymine
Trifluorothymine is an antitumor and antiviral agent. Trifluorothymine was found in patientsтАЩ urine as a metabolite of Trifluorothymidine as cancer treatment.
What are the applications of Application
Trifluorothymine (5-(Trifluoromethyl)uracil) is an application medicine intermediate widely. It may be used for the synthesis of the cancer therapy drug trifluridine and also can be used for the preparation of the 2, 4-dichloro-5-trifluoromethyluracil.
Synthesis
Uracil and sodium triflate can be used as raw materials to synthesize Trifluorothymine. This reaction uses a mixed solvent of methylene chloride and water as the reaction solvent and tert-butyl hydroperoxide as the catalyst.
Properties of Trifluorothymine
| Melting point: | 245-246 °C(lit.) |
| Density | 1.5484 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | methanol: soluble50mg/mL, clear |
| form | powder to crystal |
| pka | 6.63±0.10(Predicted) |
| color | White to Orange to Green |
| Water Solubility | INSOLUBLE |
| BRN | 612694 |
| CAS DataBase Reference | 54-20-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4(1H,3h)-pyrimidinedione, 5-(trifluoromethyl)-(54-20-6) |
Safety information for Trifluorothymine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trifluorothymine
| InChIKey | LMNPKIOZMGYQIU-UHFFFAOYSA-N |
Abamectin manufacturer
aSai Vishwa Speciality Chemicals Pvt Ltd
1Y
Phone:+919920410867
Whatsapp: +91-9920410867
product: 54-20-6 98%
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: 5-(Trifluoromethyl)uracil
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![[2-13C,15N2]-Trifluorothymine](https://img.chemicalbook.in/)
You may like
-
54-20-6 5-TRIFLUOROMETHYLURACIL Trifluorothymine 98%View Details
54-20-6 -
54-20-6 98%View Details
54-20-6 -
5-(Trifluoromethyl)uracil CAS 54-20-6View Details
54-20-6 -
5-Trifluoromethyl Uracil CAS 54-20-6View Details
54-20-6 -
Trifluorothymine CAS 54-20-6View Details
54-20-6 -
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Lithium ClavulanateView Details
61177-44-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.