Triethylene Glycol 2-Bromoethyl Methyl Ether
- CAS NO.：110429-45-3
- Empirical Formula: C9H19BrO4
- Molecular Weight: 271.15
- MDL number: MFCD12545963
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Triethylene Glycol 2-Bromoethyl Methyl Ether?
Description
m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Triethylene Glycol 2-Bromoethyl Methyl Ether
| Boiling point: | 296.3±25.0 °C(Predicted) |
| Density | 1.256±0.06 g/cm3(Predicted) |
| refractive index | 1.4620 to 1.4660 |
| storage temp. | 2-8°C |
| form | clear liquid |
| color | White to Yellow to Green |
| CAS DataBase Reference | 110429-45-3 |
Safety information for Triethylene Glycol 2-Bromoethyl Methyl Ether
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Triethylene Glycol 2-Bromoethyl Methyl Ether
New Products
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![1-{2-[2-(2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane](https://img.chemicalbook.in/CAS/20180629/GIF/104518-25-4.gif)
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