Transglutaminase
Synonym(s):Protein-Glutamine-γ-Glutamyltransferase;Protein-glutamine:amine γ-glutamyltransferase;TGase
- CAS NO.：80146-85-6
- Empirical Formula: C27H44O3H2O
- Molecular Weight: 0
- MDL number: MFCD00132446
- EINECS: 232-554-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-29 18:21:28
What is Transglutaminase?
The Uses of Transglutaminase
transglutaminase is an enzyme said to activate the skin’s physiological functions.
The Uses of Transglutaminase
Transglutaminase has been used in a study to improve quantifiable assays to fully characterize the role of transglutaminase in diseases such as Huntington′s disease and Alzheimer′s disease.Transglutaminase has also been used in a study to develop a nonradioactive dot blot assay for transglutaminase activity.
Biochem/physiol Actions
Transglutaminase from guinea pig liver consists of a single polypeptide chain of 691 amino acid residues. It has six potential glycosylation sites (Asn-X-Ser or Asn-X-Thr), but it is not glycosylated. The molecular mass is approximately 76.6 kDa. It is calcium dependent and has several calcium binding sites. The enzyme is inhibited by iodoacetamide and N-ethylmaleimide in the presence of calcium. It catalyzes the incorporation of small molecular weight amines into γ-glutamine sites of proteins. In the absence of small molecular weight amines, it catalyzes the cross linking of proteins that results in the formation of γ-glutamyl-ε-lysine side chain peptides. Liver transglutaminase is a nonzymogenic enzyme.
Properties of Transglutaminase
| storage temp. | -20°C |
| solubility | H2O: soluble1.0mg/mL, clear |
| form | lyophilized powder |
| color | White to yellow |
Safety information for Transglutaminase
Computed Descriptors for Transglutaminase
New Products
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