TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE
Synonym(s):trans-2,3-Dimethoxy-?-nitrostyrene
- CAS NO.：37630-20-9
- Empirical Formula: C10H11NO4
- Molecular Weight: 209.2
- MDL number: MFCD00068082
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-11 17:04:31
What is TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE?
Biochem/physiol Actions
CID 5380390 (trans-2,3-Dimethoxy-?-nitrostyrene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcription, chromatin modification, and signal transduction. CID 5380390 has an IC50 values of 23 μM for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases.
Properties of TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE
| Melting point: | 80-84 °C(lit.) |
| Boiling point: | 328.3±27.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble15mg/mL (clear solution) |
| form | powder |
| color | faint yellow to dark yellow |
Safety information for TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE
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