Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
- CAS NO.：168958-19-8
- Empirical Formula: C12H19NO4
- Molecular Weight: 241.28
- MDL number: MFCD30729673
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-25 17:59:01
What is Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester?
The Uses of Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Properties of Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
| Boiling point: | 331.2±42.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| solubility | soluble in Methanol |
| pka | 11.75±0.40(Predicted) |
Safety information for Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
Computed Descriptors for Trans-(1R,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester
New Products
3-Oxocyclobutane-1-carboxylicacid 4-(Ethylaminomethyl)pyridine Ethyl 3-pyridylacetate 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Pyridin-4-ylmethanol hydrobromide Trans-methyl 4-aminocyclohexane- carboxylate HCl 1-Indanone 4-Chloro Phenyl hydrazine hydrochloride Nintedanib Ethanesulfonate (S)-2-(3,5-diMethylphenyl)pyrrolidine Ethyl 2-(4-(chlorosulfonyl)-2-methylphenoxy)acetate (2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxylic acid (R)-1-phenylethan-1-amine salt 1-Bromo-2-Methoxy-3-Nitrobenzene N N N'Trimethyl ethylenediamine N Ethylmethylamine Ethyl Methanesulfonate Variamine Blue B Diazonium salt Lead II Bromide N N' DimethylEthylenediamine L-Glycine methyl ester.HCl Calcium Alphaketoglutarate* Fmoc-L-Glu(OtBu)-OH.H2O H-Ser(t-Bu)-Ser(t-Bu)-Gly-OH Fmoc-Ser(tBu)-Ser(Ψ(Me,Me)pro-OHRelated products of tetrahydrofuran
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