TN ANTIGEN
Synonym(s):GalNac-α-1-O-serine;O-[2-(Acetylamino)-2-deoxy-α-D -galactopyranosyl]-L -serine
- CAS NO.:67262-86-6
- Empirical Formula: C11H20N2O8
- Molecular Weight: 308.29
- MDL number: MFCD01863462
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is TN ANTIGEN?
Chemical properties
TN ANTIGEN is Yellow Solid
The Uses of TN ANTIGEN
TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines
The Uses of TN ANTIGEN
A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines.
What are the applications of Application
Tn Epitope is a tumor antigen
Definition
ChEBI: O-(N-acetyl-alpha-D-galactosaminyl)-L-serine is a non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine. It has a role as a tumour antigen. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid.
General Description
Tn antigen?is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
Properties of TN ANTIGEN
Melting point: | 198-201°C |
Boiling point: | 701.2±60.0 °C(Predicted) |
Density | 1.51±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Water |
form | Solid |
pka | 2.05±0.10(Predicted) |
color | Off-White to Yellow |
Stability: | HYGROSCOPIC |
Safety information for TN ANTIGEN
Computed Descriptors for TN ANTIGEN
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