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HomeProduct name listTISSUE PLASMINOGEN ACTIVATOR, HUMAN

TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Synonym(s):tPA

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Structural

What is TISSUE PLASMINOGEN ACTIVATOR, HUMAN?

Chemical properties

off-white powder

The Uses of TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.

General Description

Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.

Biochem/physiol Actions

tPA is a potent activator of fibrinolysis and converts plasminogen into plasmin and also initiates cell signaling. The plasminogen activation system may also be associated with degradation of amyloid fibrils. It is also known to mediate inflammatory and extracellular matrix remodeling processes and is predicted to participate in disease progression of intracranial aneurysm indicating brain vascular malformations. Upregulation of the gene is observed in aortic aneurysms.

Properties of TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Melting point: 262 °C
Boiling point: 723.8±53.0 °C(Predicted)
Density  1.194±0.06 g/cm3(Predicted)
storage temp.  2-8°C
form  Lyophilized
pka -0.33±0.50(Predicted)
color  Light yellow to Yellow to Orange

Safety information for TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TISSUE PLASMINOGEN ACTIVATOR, HUMAN

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