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HomeProduct name listthiocolchicine

thiocolchicine

Synonym(s):10-Demethoxy-10-(methylthio)colchicine;10-Thio-colchicine;N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide;NSC 186301

  • CAS NO.:2730-71-4
  • Empirical Formula: C22H25NO5S
  • Molecular Weight: 415.5
  • MDL number: MFCD01736965
  • EINECS: 220-346-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:02:20
thiocolchicine Structural

What is thiocolchicine?

Chemical properties

Bright Yellow Solid

The Uses of thiocolchicine

A muscle relaxant.

What are the applications of Application

Thiocolchicine is a specific tubulin synthesis inhibitor and Topo I inhibitor

Biochem/physiol Actions

Thiocolchicine is an antimitotic alkaloid and apoptosis inducer that inhibits tubulin polymerization and microtubule assembly.

Properties of thiocolchicine

Melting point: 193℃
Boiling point: 729.1±60.0 °C(Predicted)
alpha  D20 -221°
Density  1.27±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: soluble10mg/mL, clear
pka 14.75±0.40(Predicted)
form  powder
color  white to beige

Safety information for thiocolchicine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H318:Serious eye damage/eye irritation
H340:Germ cell mutagenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for thiocolchicine

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