Thiazolidine-4-carboxylic acid

CAS NO.：444-27-9
Empirical Formula: C4H7NO2S
Molecular Weight: 133.17
MDL number: MFCD00128958
EINECS: 207-146-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is Thiazolidine-4-carboxylic acid?

Originator

Hepaldine,Riker,France,1964

The Uses of Thiazolidine-4-carboxylic acid

hepatoprotectant

The Uses of Thiazolidine-4-carboxylic acid

Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells.

Definition

ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.

Manufacturing Process

Cysteine is first dissolved in distilled water which has been freed of oxygen by boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and the temperature of the mixture rises, while the thiazolidine carboxylic acid begins crystallizing. The stirring is continued for 2 hours after which ethyl alcohol of 95% (w/v) concentration is added to induce further crystallization. The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered with retention of a crude product, which is purified by recrystallization from boiling distilled water. The crystals are then dried at about 40°C. The free acid is then converted to the sodium salt with NaOH.

Therapeutic Function

Hepatoprotectant, Choleretic

Properties of Thiazolidine-4-carboxylic acid

Melting point:	196.5°C
Boiling point:	350.3±37.0 °C(Predicted)
Density	1.226 (estimate)
refractive index	1.5480 (estimate)
storage temp.	Room Temperature
solubility	DMSO (Slightly), Water (Slightly)
pka	2.09±0.20(Predicted)
form	solid
color	White to off-white
Water Solubility	29.3g/L(21 ºC)
CAS DataBase Reference	444-27-9(CAS DataBase Reference)
EPA Substance Registry System	4-Thiazolidinecarboxylic acid (444-27-9)

Safety information for Thiazolidine-4-carboxylic acid

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…