Thiazolidine-4-carboxylic acid
- CAS NO.:444-27-9
- Empirical Formula: C4H7NO2S
- Molecular Weight: 133.17
- MDL number: MFCD00128958
- EINECS: 207-146-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-29 15:17:36
What is Thiazolidine-4-carboxylic acid?
Originator
Hepaldine,Riker,France,1964
The Uses of Thiazolidine-4-carboxylic acid
hepatoprotectant
The Uses of Thiazolidine-4-carboxylic acid
Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells.
Definition
ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.
Manufacturing Process
Cysteine is first dissolved in distilled water which has been freed of oxygen by boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and the temperature of the mixture rises, while the thiazolidine carboxylic acid begins crystallizing. The stirring is continued for 2 hours after which ethyl alcohol of 95% (w/v) concentration is added to induce further crystallization. The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered with retention of a crude product, which is purified by recrystallization from boiling distilled water. The crystals are then dried at about 40°C. The free acid is then converted to the sodium salt with NaOH.
Therapeutic Function
Hepatoprotectant, Choleretic
Properties of Thiazolidine-4-carboxylic acid
Melting point: | 196.5°C |
Boiling point: | 350.3±37.0 °C(Predicted) |
Density | 1.226 (estimate) |
refractive index | 1.5480 (estimate) |
storage temp. | Room Temperature |
solubility | DMSO (Slightly), Water (Slightly) |
pka | 2.09±0.20(Predicted) |
form | solid |
color | White to off-white |
Water Solubility | 29.3g/L(21 ºC) |
CAS DataBase Reference | 444-27-9(CAS DataBase Reference) |
EPA Substance Registry System | 4-Thiazolidinecarboxylic acid (444-27-9) |
Safety information for Thiazolidine-4-carboxylic acid
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for Thiazolidine-4-carboxylic acid
New Products
Tubulysin I Tubulysin C (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin H 2,2-Difluoropropylamine hydrochloride 1-(1,1-Difluoroethyl)-2-fluorobenzene CYCLOBUTYLAMINE HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE 4,4-DIFLUOROPIPERIDINE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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