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HomeProduct name listThalidomide-O-amido-C8-NH2 hydrochloride

Thalidomide-O-amido-C8-NH2 hydrochloride

  • CAS NO.:2415263-07-7
  • Empirical Formula: C23H31ClN4O6
  • Molecular Weight: 494.97
  • Update Date: 2024-04-01 13:48:23
Thalidomide-O-amido-C8-NH2 hydrochloride Structural

What is Thalidomide-O-amido-C8-NH2 hydrochloride?

Biological Activity

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1].

storage

Desiccate at RT

References

[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Safety information for Thalidomide-O-amido-C8-NH2 hydrochloride

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