TERT-BUTYL 4-BROMOBENZYLCARBAMATE
- CAS NO.:68819-84-1
- Empirical Formula: C12H16BrNO2
- Molecular Weight: 286.16
- MDL number: MFCD08703140
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-09 16:41:59
What is TERT-BUTYL 4-BROMOBENZYLCARBAMATE?
Synthesis
Tert-Butyl 4-bromobenzylcarbamate is prepared by the reaction of di-tert-butyl dicarbonate and 4-bromobenzylamine hydrochloride. The specific synthesis steps are as follows:
To a stirred suspension of 4-bromo-benzylamine hydrochloride (968mg, 4.35mmol) and triethylamine (0.666ml, 4.79mmol) in chloroform (15ml) was added di-tert-butyldicarbonate (949mg, 4.35mmol). The resulting solution was stirred at ambient temperature for 2h and then diluted with DCM (40ml). The organic solution was washed sequentially with 10% aqueous citric acid (40ml) and brine (40ml). The organic phase was dried over anhydrous magnesium sulfate and the filtrate evaporated at reduced pressure to afford Tert-Butyl 4-bromobenzylcarbamate (1.23g, 99%). 1H NMR 7.48-7.43 (2H, m), 7.18 (2H, d, 8.4), 4.84 (1H, br s), 4.27 (2H, d, 5.7), 1.46 (9H, s).
Properties of TERT-BUTYL 4-BROMOBENZYLCARBAMATE
Melting point: | 86-88℃ |
Boiling point: | 374.3±25.0 °C(Predicted) |
Density | 1.319±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
pka | 12.05±0.46(Predicted) |
color | Off-white |
Safety information for TERT-BUTYL 4-BROMOBENZYLCARBAMATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for TERT-BUTYL 4-BROMOBENZYLCARBAMATE
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