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HomeProduct name listTERT-BUTYL 4-BROMOBENZYLCARBAMATE

TERT-BUTYL 4-BROMOBENZYLCARBAMATE

TERT-BUTYL 4-BROMOBENZYLCARBAMATE Structural

What is TERT-BUTYL 4-BROMOBENZYLCARBAMATE?

Synthesis

Tert-Butyl 4-bromobenzylcarbamate is prepared by the reaction of di-tert-butyl dicarbonate and 4-bromobenzylamine hydrochloride. The specific synthesis steps are as follows:
To a stirred suspension of 4-bromo-benzylamine hydrochloride (968mg, 4.35mmol) and triethylamine (0.666ml, 4.79mmol) in chloroform (15ml) was added di-tert-butyldicarbonate (949mg, 4.35mmol). The resulting solution was stirred at ambient temperature for 2h and then diluted with DCM (40ml). The organic solution was washed sequentially with 10% aqueous citric acid (40ml) and brine (40ml). The organic phase was dried over anhydrous magnesium sulfate and the filtrate evaporated at reduced pressure to afford Tert-Butyl 4-bromobenzylcarbamate (1.23g, 99%). 1H NMR 7.48-7.43 (2H, m), 7.18 (2H, d, 8.4), 4.84 (1H, br s), 4.27 (2H, d, 5.7), 1.46 (9H, s).
TERT-BUTYL 4-BROMOBENZYLCARBAMATE synthesis

Properties of TERT-BUTYL 4-BROMOBENZYLCARBAMATE

Melting point: 86-88℃
Boiling point: 374.3±25.0 °C(Predicted)
Density  1.319±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
pka 12.05±0.46(Predicted)
color  Off-white

Safety information for TERT-BUTYL 4-BROMOBENZYLCARBAMATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for TERT-BUTYL 4-BROMOBENZYLCARBAMATE

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