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HomeProduct name listTamsulosin hydrochloride

Tamsulosin hydrochloride

Synonym(s):5-[2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Tamsulosin hydrochloride Structural

What is Tamsulosin hydrochloride?

Chemical properties

White to Off-White Solid

The Uses of Tamsulosin hydrochloride

Tamsulosin hydrochloride is a specific ;1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

The Uses of Tamsulosin hydrochloride

Tamsulosin is a specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Clinical Use

Treatment of benign prostatic hyperplasia

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antifungals: concentration increased by ketoconazole.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid concomitant use.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension.

Metabolism

Tamsulosin is metabolised slowly in the liver primarily by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4; it is excreted mainly in the urine as metabolites and some unchanged drug

Properties of Tamsulosin hydrochloride

Melting point: 254-256 °C
solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  neat

Safety information for Tamsulosin hydrochloride

Computed Descriptors for Tamsulosin hydrochloride

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