TAFENOQUINE SUCCINATE

Synonym(s):N-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine;SB-252263;WR 238605

CAS NO.：106635-81-8
Empirical Formula: C28H34F3N3O7
Molecular Weight: 581.5806696
MDL number: MFCD00892249
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-20 16:43:00

What is TAFENOQUINE SUCCINATE?

The Uses of TAFENOQUINE SUCCINATE

Tafenoquine succinate is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the preven tion and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.

The Uses of TAFENOQUINE SUCCINATE

Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.

Biochem/physiol Actions

Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis.

Properties of TAFENOQUINE SUCCINATE

Melting point:	146-149°
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL (clear solution)
form	powder
color	white to beige

Safety information for TAFENOQUINE SUCCINATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.