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HomeProduct name listTadalafil-d3

Tadalafil-d3

Tadalafil-d3 Structural

What is Tadalafil-d3?

Description

Tadalafil-d3 is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

Chemical properties

Tadalafil-d3 is White Solid

The Uses of Tadalafil-d3

Tadalafil-d3 is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Intended for use as an internal standard for the quantification of Tadalafil by GC- or LC-mass spectrometry.

The Uses of Tadalafil-d3

Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.

Properties of Tadalafil-d3

Melting point: 281-283°C
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), DMSO (Slightly)
form  Solid
color  White to Off-White
Stability: Unstable in Methanol
InChI InChI=1/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/s3

Safety information for Tadalafil-d3

Computed Descriptors for Tadalafil-d3

InChIKey WOXKDUGGOYFFRN-PDIFIXMTNA-N
SMILES c12c3ccccc3nc1[C@H](c1cc3OCOc3cc1)N1C(=O)CN(C)C(=O)[C@H]1C2 |&1:9,27,r|

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