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HomeProduct name listSulfacarbamide

Sulfacarbamide

  • CAS NO.:547-44-4
  • Empirical Formula: C7H9N3O3S
  • Molecular Weight: 215.23
  • MDL number: MFCD00025437
  • EINECS: 208-922-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 11:59:05
Sulfacarbamide Structural

What is Sulfacarbamide?

Description

Sulfacarbamide is a blood sugar-lowering drug, also acting on the vegetative nervous system.

Chemical properties

White solid

The Uses of Sulfacarbamide

antibacterial

The Uses of Sulfacarbamide

Sulfacarbamide-d4 is the labeled analogue of Sulfacarbamide (S688945), an antibiotic which is rapidly absorbed in blister fluid.

Definition

ChEBI: Sulfacarbamide is a sulfonamide and a member of benzenes.

World Health Organization (WHO)

Sulfacarbamide, a sulfonamide anti-infective agent, was introduced in the 1940's for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The Sulfacarbamide are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfacarbamide still remains available in at least one country for the treatment of urinary infections.

Mechanism of action

Sulfonylureas bind to and inhibit the ATP-sensitive potassium channels (K) on the pancreatic beta cells. As a result, potassium efflux decreases, and the beta-cell membrane depolarizes. Membrane depolarization causes calcium channels to open, leading to calcium influx and increased intracellular calcium, which stimulates insulin secretion from the pancreatic beta cells. Sulfonylureas cause insulin release regardless of blood glucose levels.

Properties of Sulfacarbamide

Melting point: 146-148° (slight dec)
Density  1.4565 (rough estimate)
refractive index  1.6630 (estimate)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  DMSO : ≥ 28 mg/mL (130.09 mM)
form  Solid
pka pKa 1.78(H2O t = 25 I = 0.05) (Uncertain);5.42(H2O t = 25 I = 0.05) (Uncertain)
color  White to off-white
Water Solubility  2.333g/L(20 ºC)
InChI InChI=1S/C7H9N3O3S/c8-5-1-3-6(4-2-5)14(12,13)10-7(9)11/h1-4H,8H2,(H3,9,10,11)

Safety information for Sulfacarbamide

Computed Descriptors for Sulfacarbamide

InChIKey WVAKABMNNSMCDK-UHFFFAOYSA-N
SMILES C1(S(NC(N)=O)(=O)=O)=CC=C(N)C=C1

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