STATIL
- CAS NO.:72702-95-5
- Empirical Formula: C17H12BrFN2O3
- Molecular Weight: 391.19
- MDL number: MFCD00204117
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is STATIL?
Description
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.
The Uses of STATIL
Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth
The Uses of STATIL
Inhibitor (aldose reductase).
Definition
ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.
What are the applications of Application
Statil is an aldose reductase inhibitor
Biological Activity
Potent aldose reductase inhibitor.
Properties of STATIL
Melting point: | 184-186℃ (DEC.) |
Density | 1.60 |
storage temp. | Store at RT |
solubility | DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL |
form | A crystalline solid |
color | White to off-white |
Safety information for STATIL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for STATIL
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 4-Hydrazinobenzoic acid Electrolytic Iron Powder 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 4-HYDROXY BENZYL ALCOHOL 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) S-2-CHLORO PROPIONIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 6-Bromo-3-iodo-1-methyl-1H-indazole N-Boc-L-proline methyl ester 2-(BOC-Amino)4-picoline 1-(4-Methylphenylsulfonyl)-1H-1,2,3-benzotriazole 1-(2-Chlorobenzyl)-4-nitro-1H-pyrazoleRelated products of tetrahydrofuran
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