ST072042

CAS NO.：88349-90-0
Empirical Formula: C13H12ClNO3
Molecular Weight: 265.69
MDL number: MFCD04275530
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is ST072042?

Biological Activity

A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK .

in vitro

A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.

Properties of ST072042

Boiling point:	393.4±27.0 °C(Predicted)
Density	1.291±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 100 mg/mL (376.38 mM)
pka	1.97±0.29(Predicted)
form	Solid
color	White to off-white

Safety information for ST072042

Computed Descriptors for ST072042

New Products

4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acid