SR3335

Synonym(s):;N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide;

CAS NO.：293753-05-6
Empirical Formula: C13H9F6NO3S2
Molecular Weight: 405.3358792
MDL number: MFCD02724814
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-11 14:41:12

What is SR3335?

Description

The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (K_i = 220 nM) and inhibiting constitutive transactivation activity (IC₅₀ = 480 nM). It is without effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis.

Definition

ChEBI: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-thiophenesulfonamide is a sulfonamide.

Properties of SR3335

storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	insoluble in H2O; ≥87.4 mg/mL in EtOH; ≥88.8 mg/mL in DMSO
form	solid
color	White to off-white

Safety information for SR3335

Computed Descriptors for SR3335

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