SR 12813
- CAS NO.：126411-39-0
- Empirical Formula: C24H42O7P2
- Molecular Weight: 504.53
- MDL number: MFCD00888473
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:37
What is SR 12813?
The Uses of SR 12813
SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.
What are the applications of Application
SR 12813 is a PXR agonist that activates the farnesoid X receptor (FXR) at μM concentrations
Definition
ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).
Biological Activity
Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
Biochem/physiol Actions
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.
storage
Store at +4°C
Properties of SR 12813
| Melting point: | 119-121℃ |
| Boiling point: | 552.6±50.0 °C(Predicted) |
| Density | 1.117±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: ≥10 mg/mL |
| form | solid |
| pka | 9.95±0.70(Predicted) |
| color | White to off-white |
Safety information for SR 12813
Computed Descriptors for SR 12813
New Products
Tubulysin D Tubulysin I Tubulysin E Tubulysin F CYCLOBUTYLAMINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-Aminocyclobutanone hydrochloride 2H-Pyran, 4-ethynyltetrahydro- 1-(1,1-Difluoroethyl)-2-fluorobenzene 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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