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HomeProduct name listSR 12813

SR 12813

SR 12813 Structural

What is SR 12813?

The Uses of SR 12813

SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.

What are the applications of Application

SR 12813 is a PXR agonist that activates the farnesoid X receptor (FXR) at μM concentrations

Definition

ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).

Biological Activity

Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

Biochem/physiol Actions

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.

storage

Store at +4°C

Properties of SR 12813

Melting point: 119-121℃
Boiling point: 552.6±50.0 °C(Predicted)
Density  1.117±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO: ≥10 mg/mL
form  solid
pka 9.95±0.70(Predicted)
color  White to off-white

Safety information for SR 12813

Computed Descriptors for SR 12813

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