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HomeProduct name listSQUALESTATIN

SQUALESTATIN

Synonym(s):L-694,599;Squalestatin

  • CAS NO.:144541-82-2
  • Empirical Formula: C35H47NaO14
  • Molecular Weight: 714.74
  • MDL number: MFCD03788025
SQUALESTATIN Structural

What is SQUALESTATIN?

The Uses of SQUALESTATIN

Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase.

The Uses of SQUALESTATIN

Zaragozic acid A trisodium salt has been used as:

  • a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
  • a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
  • a cholesterol synthesis inhibitor in T cells

What are the applications of Application

Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase. It has been used as a cholesterol synthesis inhibitor in T cells.

Biochem/physiol Actions

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Properties of SQUALESTATIN

storage temp.  -20°C

Safety information for SQUALESTATIN

Computed Descriptors for SQUALESTATIN

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